Soluble receptor activator of nuclear factor-kB ligand (RANKL) and osteoprotegerin in ankylosing spondylitis: OPG is associated with poor physical mobility and reflects systemic inflammation

Chun Hsiung Chen, Hung An Chen, Hsien Tzung Liao, Chin Hsiu Liu, Chang Youh Tsai, Chung Tei Chou

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32 引文 斯高帕斯(Scopus)

摘要

The objective of the study was to investigate the role of receptor activator of nuclear factor-kB ligand (RANKL) and osteoprotegerin (OPG) in ankylosing spondylitis (AS). Serum levels of soluble RANKL (sRANKL) and OPG were measured in 42 AS patients and 26 healthy controls. We evaluated the AS patient's disease activity, functional ability, global assessment, and physical mobility and tested markers of systemic inflammation, erythrocyte sedimentation rate (ESR), and Creactive protein (CRP) levels. Serum levels of sRANKL [mean (SD), 4.75 (1.88) vs. 3.70 (1.14) pmol/l, p=0.015] and OPG [mean (SD), 5.18 (1.19) vs. 4.52 (0.85) pmol/l, p=0.026] were significantly higher in the 42 AS patients than the 26 healthy controls. Interestingly, serum OPG levels correlated significantly with ESR (r=0.417, p= 0.007), CRP (r=0.524, p

原文英語
頁(從 - 到)1155-1161
頁數7
期刊Clinical Rheumatology
29
發行號10
DOIs
出版狀態已發佈 - 2010

ASJC Scopus subject areas

  • Rheumatology

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