Soluble interleukin-10 and transforming growth factor-β in children with acute exacerbation of allergic asthma

Tzu Chun Tsai, Jen Her Lu, Shu Jen Chen, Ren Bin Tang

研究成果: 雜誌貢獻文章同行評審

15 引文 斯高帕斯(Scopus)

摘要

Cytokine-mediated interactions among inflammatory cells may contribute to pathogenesis of allergic asthma. To understand the role of soluble interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) on the disease activity and regulation in asthma, changes in serum concentrations of IL-10 and TGF-β elaborated by activated T-lymphocyte before and after prednisolone therapy with clinical improvement were determined. Circulating levels of IL-10 and TGF-β in sera from 16 normal control subjects and in sera from 22 allergic asthmatic children with acute exacerbation and in stable condition were respectively detected by commercially available enzyme-linked immunosorbent assay kits. The mean concentrations of serum IL-10 in asthmatics with acute exacerbation (6.77 ± 4.08 pg/mL) and during stable condition (5.14 ± 1.17 pg/mL) were lower than that in control subjects (7.15 ± 4.72 pg/mL). However, the difference was not statistically significant among these three study groups. The mean concentration of serum TGF-β in stable asthmatics (40.73 ± 15.95 pg/mL) was significantly higher than that in asthmatics with acute exacerbation (27.64 ± 3.66 pg/mL; p < 0.05) and that in healthy control group (28.77 ± 8.35 pg/mL; p < 0.05), while there was no statistical difference between the latter two groups. This study provides further evidence that serum TGF-β, rather than IL-10, may play a role in regulation of disease activity and serve as an indicator for clinical control of allergic asthmatics.

原文英語
頁(從 - 到)21-24
頁數4
期刊Journal of Asthma
46
發行號1
DOIs
出版狀態已發佈 - 2月 2009
對外發佈

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康
  • 免疫學和過敏
  • 肺和呼吸系統醫學

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