A case of 65-year-old female with intrasellar mass was operated on under the diagnosis of pituitary adenoma. The final diagnosis of plasmacytoma was made by immunocytochemical stain of IgG and electron microscopical findings. Postoperatively, the radiological studies of systemic skeletal bone and cytology of bone marrow were normal. However, the serum IgG was high, and the urinary Bence-Jones protein (kappa type) was positive. Although these laboratory data normalized after operation and irradiation, the patient converted to severe multiple myeloma and expired one and half year after operation.
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