Small cell lung carcinoma: Clinicopathological, immunohistochemical, and ultrastructural study

S. W. Shy, W. H. Lee, M. C. Chou, Y. S. Lai, Y. C. Tu

研究成果: 雜誌貢獻文章

29 引文 (Scopus)

摘要

Sixty-seven cases of small cell lung carcinoma (SCLA) in Tri-Service General Hospital (TSGH) during the past 16 years were studied. For patients with extensive stage of disease, the mean survival time and 2-year survival rate were 7.2 months and 3.1% versus 13.4 months and 16.7% for patients with limited stage. A better prognosis was obtained by treatment with a combination of intensive chemotherapy and radiotherapy. Immunohistochemical studies were performed by the peroxidase-antiperoxidase method. The positive rates in descending order were bombesin (80%), synaptophysin (74.3%), neurofilament (68.6%), neuron-specific enolase (60%), low molecular weight cytokeratin (54.3%), high molecular weight cytokeratin (25.7%), chromogranin-A (22.9%), adrenocorticotrophic hormone (0). Seven cases were examined and found to be ultrastructure; only 3 cases were found to contain neurosecretory granules. We emphasize that electron microscopy is not necessary as a routine diagnostic procedure, while light microscopy should be employed whenever possible; the immunohistochemical study should be considered within this context.

原文英語
頁(從 - 到)146-161
頁數16
期刊Journal of Surgical Oncology
45
發行號3
出版狀態已發佈 - 1990
對外發佈Yes

指紋

Small Cell Lung Carcinoma
Keratins
Survival Rate
Molecular Weight
Chromogranin A
Bombesin
Synaptophysin
Intermediate Filaments
Phosphopyruvate Hydratase
Combination Drug Therapy
General Hospitals
Adrenocorticotropic Hormone
Peroxidase
Microscopy
Electron Microscopy
Radiotherapy
Light
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Surgery

引用此文

Small cell lung carcinoma : Clinicopathological, immunohistochemical, and ultrastructural study. / Shy, S. W.; Lee, W. H.; Chou, M. C.; Lai, Y. S.; Tu, Y. C.

於: Journal of Surgical Oncology, 卷 45, 編號 3, 1990, p. 146-161.

研究成果: 雜誌貢獻文章

Shy, S. W. ; Lee, W. H. ; Chou, M. C. ; Lai, Y. S. ; Tu, Y. C. / Small cell lung carcinoma : Clinicopathological, immunohistochemical, and ultrastructural study. 於: Journal of Surgical Oncology. 1990 ; 卷 45, 編號 3. 頁 146-161.
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