Skin tumor-promoting potential and systemic effects of pentachlorophenol and its major metabolite tetrachlorohydroquinone in CD-1 mice

Wen Ching Chang, Jiiang Huei Jeng, Chi Chang Shieh, Yi Chang Tsai, Yuan Soon Ho, How Ran Guo, Hsin I. Liu, Ching Chang Lee, Sheng Yow Ho, Ying Jan Wang

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

The mouse skin carcinogenesis model provides a conceptual framework to study the carcinogenesis process. It has been used extensively to assess whether a chemical or physical agent carries a carcinogenic hazard to humans and to define the mechanism involved with the carcinogenic effects. We conducted a study to evaluate whether the tumor-promoting activity of pentachlorophenol (PCP) is mainly from its major metabolite tetrachlorohydroquinone (TCHQ). We applied the mouse skin model to CD-1 mice and the results showed that PCP and TCHQ are much weaker promoters than 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin during a 25-wk experiment. Both PCP and TCHQ could induce mice skin epidermal hyperplasia and proliferating cell nuclear antigen (PCNA) labeling index in the epidermis. However, TCHQ caused a more significant induction of epidermal hyperplasia and PCNA positive cells than PCP. Topical application of PCP, but not TCHQ, induced significant organ enlargement and lymphoma in mice, whereas short-term treatment of TCHQ increased tumor necrosis factor-α (TNF-α) gene expression in mouse skin. We did not observe a significant association between the carcinogenic process and serum TNF-α or interleukin-1β (IL-1β) levels in mice.

原文英語
頁(從 - 到)161-170
頁數10
期刊Molecular Carcinogenesis
36
發行號4
DOIs
出版狀態已發佈 - 四月 1 2003

ASJC Scopus subject areas

  • 癌症研究
  • 分子生物學

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