Skewed distribution of IL-7 receptor-a-expressing effector memory CD8 + T cells with distinct functional characteristics in oral squamous cell carcinoma

Jang Jaer Lee, Chiou Yueh Yeh, Chiau-Jing Jung, Ching Wen Chen, Mao Kuang Du, Hui Ming Yu, Chia Ju Yang, Hui Yi Lin, Andy Sun, Jenq Yuh Ko, Shih Jung Cheng, Yen Liang Chang, Jean-San Chia

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

CD8+ T cells play important roles in anti-tumor immunity but distribution profile or functional characteristics of effector memory subsets during tumor progression are unclear. We found that, in oral squamous carcinoma patients, circulating CD8+ T cell pools skewed toward effector memory subsets with the distribution frequency of CCR7-CD45RA -CD8+ T cells and CCR7- CD45RA +CD8+ T cells negatively correlated with each other. A significantly higher frequency of CD127lo CCR7-CD45RA -CD8+ T cells or CCR7-CD45RA +CD8+ T cells among total CD8+ T cells was found in peripheral blood or tumor infiltrating lymphocytes, but not in regional lymph nodes. The CD127hi CCR7-CD45RA-CD8 + T cells or CCR7-CD45RA+CD8+ T cells maintained significantly higher IFN-γ, IL-2 productivity and ex vivo proliferative capacity, while the CD127lo CCR7 -CD45RA-CD8+ T cells or CCR7 -CD45RA+CD8+ T cells exhibited higher granzyme B productivity and susceptibility to activation induced cell death. A higher ratio of CCR7-CD45RA+CD8+ T cells to CCR7 -CD45RA-CD8+ T cells was associated with advanced cancer staging and poor differentiation of tumor cells. Therefore, the CD127lo CCR7-CD45RA-CD8+ T cells and CCR7-CD45RA+CD8+ T cells are functionally similar CD8+ T cell subsets which exhibit late differentiated effector phenotypes and the shift of peripheral CD8+ effector memory balance toward CCR7-CD45RA+ CD8+ T cells is associated with OSCC progression.
原文英語
文章編號e85521
期刊PLoS One
9
發行號1
DOIs
出版狀態已發佈 - 一月 23 2014
對外發佈Yes

指紋

Interleukin-7 Receptors
interleukin-7
T-cells
squamous cell carcinoma
functional properties
Squamous Cell Carcinoma
mouth
T-lymphocytes
T-Lymphocytes
Data storage equipment
receptors
Tumors
Epithelial Cells
neoplasms
Productivity
Efficiency
Tumor-Infiltrating Lymphocytes
Granzymes
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

引用此文

Skewed distribution of IL-7 receptor-a-expressing effector memory CD8 + T cells with distinct functional characteristics in oral squamous cell carcinoma. / Lee, Jang Jaer; Yeh, Chiou Yueh; Jung, Chiau-Jing; Chen, Ching Wen; Du, Mao Kuang; Yu, Hui Ming; Yang, Chia Ju; Lin, Hui Yi; Sun, Andy; Ko, Jenq Yuh; Cheng, Shih Jung; Chang, Yen Liang; Chia, Jean-San.

於: PLoS One, 卷 9, 編號 1, e85521, 23.01.2014.

研究成果: 雜誌貢獻文章

Lee, JJ, Yeh, CY, Jung, C-J, Chen, CW, Du, MK, Yu, HM, Yang, CJ, Lin, HY, Sun, A, Ko, JY, Cheng, SJ, Chang, YL & Chia, J-S 2014, 'Skewed distribution of IL-7 receptor-a-expressing effector memory CD8 + T cells with distinct functional characteristics in oral squamous cell carcinoma', PLoS One, 卷 9, 編號 1, e85521. https://doi.org/10.1371/journal.pone.0085521
Lee, Jang Jaer ; Yeh, Chiou Yueh ; Jung, Chiau-Jing ; Chen, Ching Wen ; Du, Mao Kuang ; Yu, Hui Ming ; Yang, Chia Ju ; Lin, Hui Yi ; Sun, Andy ; Ko, Jenq Yuh ; Cheng, Shih Jung ; Chang, Yen Liang ; Chia, Jean-San. / Skewed distribution of IL-7 receptor-a-expressing effector memory CD8 + T cells with distinct functional characteristics in oral squamous cell carcinoma. 於: PLoS One. 2014 ; 卷 9, 編號 1.
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title = "Skewed distribution of IL-7 receptor-a-expressing effector memory CD8 + T cells with distinct functional characteristics in oral squamous cell carcinoma",
abstract = "CD8+ T cells play important roles in anti-tumor immunity but distribution profile or functional characteristics of effector memory subsets during tumor progression are unclear. We found that, in oral squamous carcinoma patients, circulating CD8+ T cell pools skewed toward effector memory subsets with the distribution frequency of CCR7-CD45RA -CD8+ T cells and CCR7- CD45RA +CD8+ T cells negatively correlated with each other. A significantly higher frequency of CD127lo CCR7-CD45RA -CD8+ T cells or CCR7-CD45RA +CD8+ T cells among total CD8+ T cells was found in peripheral blood or tumor infiltrating lymphocytes, but not in regional lymph nodes. The CD127hi CCR7-CD45RA-CD8 + T cells or CCR7-CD45RA+CD8+ T cells maintained significantly higher IFN-γ, IL-2 productivity and ex vivo proliferative capacity, while the CD127lo CCR7 -CD45RA-CD8+ T cells or CCR7 -CD45RA+CD8+ T cells exhibited higher granzyme B productivity and susceptibility to activation induced cell death. A higher ratio of CCR7-CD45RA+CD8+ T cells to CCR7 -CD45RA-CD8+ T cells was associated with advanced cancer staging and poor differentiation of tumor cells. Therefore, the CD127lo CCR7-CD45RA-CD8+ T cells and CCR7-CD45RA+CD8+ T cells are functionally similar CD8+ T cell subsets which exhibit late differentiated effector phenotypes and the shift of peripheral CD8+ effector memory balance toward CCR7-CD45RA+ CD8+ T cells is associated with OSCC progression.",
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T1 - Skewed distribution of IL-7 receptor-a-expressing effector memory CD8 + T cells with distinct functional characteristics in oral squamous cell carcinoma

AU - Lee, Jang Jaer

AU - Yeh, Chiou Yueh

AU - Jung, Chiau-Jing

AU - Chen, Ching Wen

AU - Du, Mao Kuang

AU - Yu, Hui Ming

AU - Yang, Chia Ju

AU - Lin, Hui Yi

AU - Sun, Andy

AU - Ko, Jenq Yuh

AU - Cheng, Shih Jung

AU - Chang, Yen Liang

AU - Chia, Jean-San

PY - 2014/1/23

Y1 - 2014/1/23

N2 - CD8+ T cells play important roles in anti-tumor immunity but distribution profile or functional characteristics of effector memory subsets during tumor progression are unclear. We found that, in oral squamous carcinoma patients, circulating CD8+ T cell pools skewed toward effector memory subsets with the distribution frequency of CCR7-CD45RA -CD8+ T cells and CCR7- CD45RA +CD8+ T cells negatively correlated with each other. A significantly higher frequency of CD127lo CCR7-CD45RA -CD8+ T cells or CCR7-CD45RA +CD8+ T cells among total CD8+ T cells was found in peripheral blood or tumor infiltrating lymphocytes, but not in regional lymph nodes. The CD127hi CCR7-CD45RA-CD8 + T cells or CCR7-CD45RA+CD8+ T cells maintained significantly higher IFN-γ, IL-2 productivity and ex vivo proliferative capacity, while the CD127lo CCR7 -CD45RA-CD8+ T cells or CCR7 -CD45RA+CD8+ T cells exhibited higher granzyme B productivity and susceptibility to activation induced cell death. A higher ratio of CCR7-CD45RA+CD8+ T cells to CCR7 -CD45RA-CD8+ T cells was associated with advanced cancer staging and poor differentiation of tumor cells. Therefore, the CD127lo CCR7-CD45RA-CD8+ T cells and CCR7-CD45RA+CD8+ T cells are functionally similar CD8+ T cell subsets which exhibit late differentiated effector phenotypes and the shift of peripheral CD8+ effector memory balance toward CCR7-CD45RA+ CD8+ T cells is associated with OSCC progression.

AB - CD8+ T cells play important roles in anti-tumor immunity but distribution profile or functional characteristics of effector memory subsets during tumor progression are unclear. We found that, in oral squamous carcinoma patients, circulating CD8+ T cell pools skewed toward effector memory subsets with the distribution frequency of CCR7-CD45RA -CD8+ T cells and CCR7- CD45RA +CD8+ T cells negatively correlated with each other. A significantly higher frequency of CD127lo CCR7-CD45RA -CD8+ T cells or CCR7-CD45RA +CD8+ T cells among total CD8+ T cells was found in peripheral blood or tumor infiltrating lymphocytes, but not in regional lymph nodes. The CD127hi CCR7-CD45RA-CD8 + T cells or CCR7-CD45RA+CD8+ T cells maintained significantly higher IFN-γ, IL-2 productivity and ex vivo proliferative capacity, while the CD127lo CCR7 -CD45RA-CD8+ T cells or CCR7 -CD45RA+CD8+ T cells exhibited higher granzyme B productivity and susceptibility to activation induced cell death. A higher ratio of CCR7-CD45RA+CD8+ T cells to CCR7 -CD45RA-CD8+ T cells was associated with advanced cancer staging and poor differentiation of tumor cells. Therefore, the CD127lo CCR7-CD45RA-CD8+ T cells and CCR7-CD45RA+CD8+ T cells are functionally similar CD8+ T cell subsets which exhibit late differentiated effector phenotypes and the shift of peripheral CD8+ effector memory balance toward CCR7-CD45RA+ CD8+ T cells is associated with OSCC progression.

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