Size effect on cell uptake in well-suspended, uniform mesoporous silica nanoparticles

Fang Lu, Si-Han Wu, Yann Hung, Chung Yuan Mou

研究成果: 雜誌貢獻文章同行評審

782 引文 斯高帕斯(Scopus)

摘要

A study was conducted to demonstrate the synthesis of monodisperse mesoporous silica nanoparticle (MSN) suspensions and investigate the effect of nanoparticle size on cell uptake. The MSNs were synthesized by adjusting the pH of the reaction medium, leading to a series of MSNs with uniform size ranging from 30-280 nm. The physical properties of the MSNs were characterized with various methods, such as nitrogen adsorption-desorption, transmission electron microscopy (TEM), and X-ray powder diffraction (XRD). The particle size effect on the cell uptake efficiency with human cervical cancer cells and cellular uptake of MSNs of various sizes were investigated by confocal laser scanning microscopy (CLSM). The uptake efficiencies were determined by inductively coupled plasma mass spectrometry (ICP-MS) analysis of total silicon content.

原文英語
頁(從 - 到)1408-1413
頁數6
期刊Small
5
發行號12
DOIs
出版狀態已發佈 - 6月 19 2009
對外發佈

ASJC Scopus subject areas

  • 生物材料
  • 工程(雜項)
  • 生物技術

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