Simultaneous splenectomy during liver transplantation augments anti-viral therapy in patients infected with hepatitis C virus

Heng-Cheng Chu, Chung-Bao Hsieh, Kuo-Feng Hsu, Hsiu-Lung Fan, Tsai-Yuan Hsieh, Teng-Wei Chen

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

Background Simultaneous splenectomy in liver transplantation (LT) is selectively indicated because of splenoportal venous thromboses and increased sepsis. Therefore, its impact should be further investigated. Methods Of the 160 liver transplant patients, only 40 underwent simultaneous splenectomy. Clinicopathologic characteristics and outcomes were compared between the splenectomy and non-splenectomy group using retrospective analysis. Results Although the groups were similar and had no significant difference in the intra- and postoperative data, non-splenectomy group had more male patients. However, splenectomy group showed significantly higher platelet and leukocyte counts at 1 month and 6 months after the transplantation and higher hepatitis C virus anti-viral therapy completion. Furthermore, 3 patients developed portal or splenic vein thrombosis during the postoperative follow-up, but the overall survival rate did not significantly differ between these groups. Conclusion Simultaneous splenectomy in LT can be safely performed, particularly in patients with hepatitis C virus cirrhosis, small-for-size grafts, hypersplenism, and ABO blood group incompatible (ABO - incompatible) LT. © 2015 Elsevier Inc. All rights reserved.
原文英語
頁(從 - 到)180-186
頁數7
期刊American Journal of Surgery
209
發行號1
DOIs
出版狀態已發佈 - 2015
對外發佈

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