Simultaneous control of glycemic, blood pressure, and lipid significantly reduce the risk of renal progression in diabetes patients

Po-Ya Chang, Li-Nien Chien, Yuh-Feng Lin, Wen-Ta Chiu, Hung-Yi Chiou

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Background and aim Hyperglycemic, hypertension, and lipid abnormalities are risk factors for diabetic kidney disease However, no study has discussed the association of the simultaneous control of glycemic, blood pressure, and lipids with renal function among diabetes patients. Thus, this study examined the interactive effects of the intensive control of all 3 conditions on the progression of renal function. Materials and methods The study population was derived from eight hospitals in Taiwan from October 2008 to April 2015. Demographic characteristics were collected using structured questionnaires. Clinical variables were obtained from medical chart review. The renal progression was defined as a decline in the eGFR by more than 25% according to the baseline eGFR. Results Total of 1602 diabetes patients were included in the study analysis, the mean age was 63.03 ± 10.98 years, 55.56% were men. Compared to the simultaneous control of glycemic, blood pressure and lipid group, the poor control of all three diseases had the highest risk of renal progression, with an adjusted OR of 2.21 (95% CI, 1.26–3.86). Even if the patients with an intensive control of lipid, the result showed that the poor control of both glycemic and hypertension was associated with the increased risk of renal progression than the reference group. Conclusion This study demonstrated that the simultaneous poor control of glycemic, blood pressure, and lipid had the highest risk of renal progression. Thus, patients with type 2 diabetes should not only control glycemic but also manage their blood pressure and lipid.
原文英語
頁(從 - 到)87-92
頁數6
期刊European Journal of Internal Medicine
36
DOIs
出版狀態已發佈 - 十二月 1 2016

指紋

Blood Pressure
Kidney
Lipids
Hypertension
Diabetic Nephropathies
Taiwan
Type 2 Diabetes Mellitus
Demography
Control Groups
Population

ASJC Scopus subject areas

  • Internal Medicine

引用此文

@article{314ca400a9624506b7e1ec7ff3803c9d,
title = "Simultaneous control of glycemic, blood pressure, and lipid significantly reduce the risk of renal progression in diabetes patients",
abstract = "Background and aim Hyperglycemic, hypertension, and lipid abnormalities are risk factors for diabetic kidney disease However, no study has discussed the association of the simultaneous control of glycemic, blood pressure, and lipids with renal function among diabetes patients. Thus, this study examined the interactive effects of the intensive control of all 3 conditions on the progression of renal function. Materials and methods The study population was derived from eight hospitals in Taiwan from October 2008 to April 2015. Demographic characteristics were collected using structured questionnaires. Clinical variables were obtained from medical chart review. The renal progression was defined as a decline in the eGFR by more than 25{\%} according to the baseline eGFR. Results Total of 1602 diabetes patients were included in the study analysis, the mean age was 63.03 ± 10.98 years, 55.56{\%} were men. Compared to the simultaneous control of glycemic, blood pressure and lipid group, the poor control of all three diseases had the highest risk of renal progression, with an adjusted OR of 2.21 (95{\%} CI, 1.26–3.86). Even if the patients with an intensive control of lipid, the result showed that the poor control of both glycemic and hypertension was associated with the increased risk of renal progression than the reference group. Conclusion This study demonstrated that the simultaneous poor control of glycemic, blood pressure, and lipid had the highest risk of renal progression. Thus, patients with type 2 diabetes should not only control glycemic but also manage their blood pressure and lipid.",
keywords = "Diabetes, Hypertension, Lipid, Managed care, Renal disease",
author = "Po-Ya Chang and Li-Nien Chien and Yuh-Feng Lin and Wen-Ta Chiu and Hung-Yi Chiou",
year = "2016",
month = "12",
day = "1",
doi = "10.1016/j.ejim.2016.09.013",
language = "English",
volume = "36",
pages = "87--92",
journal = "European Journal of Internal Medicine",
issn = "0953-6205",
publisher = "Elsevier",

}

TY - JOUR

T1 - Simultaneous control of glycemic, blood pressure, and lipid significantly reduce the risk of renal progression in diabetes patients

AU - Chang, Po-Ya

AU - Chien, Li-Nien

AU - Lin, Yuh-Feng

AU - Chiu, Wen-Ta

AU - Chiou, Hung-Yi

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background and aim Hyperglycemic, hypertension, and lipid abnormalities are risk factors for diabetic kidney disease However, no study has discussed the association of the simultaneous control of glycemic, blood pressure, and lipids with renal function among diabetes patients. Thus, this study examined the interactive effects of the intensive control of all 3 conditions on the progression of renal function. Materials and methods The study population was derived from eight hospitals in Taiwan from October 2008 to April 2015. Demographic characteristics were collected using structured questionnaires. Clinical variables were obtained from medical chart review. The renal progression was defined as a decline in the eGFR by more than 25% according to the baseline eGFR. Results Total of 1602 diabetes patients were included in the study analysis, the mean age was 63.03 ± 10.98 years, 55.56% were men. Compared to the simultaneous control of glycemic, blood pressure and lipid group, the poor control of all three diseases had the highest risk of renal progression, with an adjusted OR of 2.21 (95% CI, 1.26–3.86). Even if the patients with an intensive control of lipid, the result showed that the poor control of both glycemic and hypertension was associated with the increased risk of renal progression than the reference group. Conclusion This study demonstrated that the simultaneous poor control of glycemic, blood pressure, and lipid had the highest risk of renal progression. Thus, patients with type 2 diabetes should not only control glycemic but also manage their blood pressure and lipid.

AB - Background and aim Hyperglycemic, hypertension, and lipid abnormalities are risk factors for diabetic kidney disease However, no study has discussed the association of the simultaneous control of glycemic, blood pressure, and lipids with renal function among diabetes patients. Thus, this study examined the interactive effects of the intensive control of all 3 conditions on the progression of renal function. Materials and methods The study population was derived from eight hospitals in Taiwan from October 2008 to April 2015. Demographic characteristics were collected using structured questionnaires. Clinical variables were obtained from medical chart review. The renal progression was defined as a decline in the eGFR by more than 25% according to the baseline eGFR. Results Total of 1602 diabetes patients were included in the study analysis, the mean age was 63.03 ± 10.98 years, 55.56% were men. Compared to the simultaneous control of glycemic, blood pressure and lipid group, the poor control of all three diseases had the highest risk of renal progression, with an adjusted OR of 2.21 (95% CI, 1.26–3.86). Even if the patients with an intensive control of lipid, the result showed that the poor control of both glycemic and hypertension was associated with the increased risk of renal progression than the reference group. Conclusion This study demonstrated that the simultaneous poor control of glycemic, blood pressure, and lipid had the highest risk of renal progression. Thus, patients with type 2 diabetes should not only control glycemic but also manage their blood pressure and lipid.

KW - Diabetes

KW - Hypertension

KW - Lipid

KW - Managed care

KW - Renal disease

UR - http://www.scopus.com/inward/record.url?scp=84994473891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994473891&partnerID=8YFLogxK

U2 - 10.1016/j.ejim.2016.09.013

DO - 10.1016/j.ejim.2016.09.013

M3 - Article

C2 - 27707566

AN - SCOPUS:84994473891

VL - 36

SP - 87

EP - 92

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

SN - 0953-6205

ER -