TY - JOUR
T1 - Similar and shared nongenomic mechanisms of action of estrogen and thyroid hormone
AU - Davis, Faith B.
AU - Lin, Hung Yun
AU - Luidens, Mary K.
AU - Zhou, Min
AU - Mousa, Shaker A.
PY - 2009
Y1 - 2009
N2 - Thyroid hormone and estrogen have nongenomic, as well as genomic, mechanisms of action. Some of these nongenomic actions of thyroid hormone and estrogen are similar or identical. For example, transduction mechanisms of thyroid hormone and estradiol signals at discrete plasma membrane hormone-binding sites of breast cancer cells, but both then utilize activation of mitogen-actrivated protein kinase (MAPK), depend upon MAPK-requiring phosphorylation of serine-118 of the nuclear estrogen receptor (ER)-α and culminate in genomically-directed, ER-dependent breast cancer cell proliferation. In this review, several mechanisms of action of estrogen and thyroid hormone are discussed that are initiated nongenomically, but, downstream of initiation sites are similar or shared. Some of these effects end genomically. The actions include hormone-directed angiogenesis, modulation of activities of plasma membrane ion transporters, regulation of the state of the actin cytoskeleton and stimulation of cancer cell proliferation, including breast and, surprisingly, thyroid cancer.
AB - Thyroid hormone and estrogen have nongenomic, as well as genomic, mechanisms of action. Some of these nongenomic actions of thyroid hormone and estrogen are similar or identical. For example, transduction mechanisms of thyroid hormone and estradiol signals at discrete plasma membrane hormone-binding sites of breast cancer cells, but both then utilize activation of mitogen-actrivated protein kinase (MAPK), depend upon MAPK-requiring phosphorylation of serine-118 of the nuclear estrogen receptor (ER)-α and culminate in genomically-directed, ER-dependent breast cancer cell proliferation. In this review, several mechanisms of action of estrogen and thyroid hormone are discussed that are initiated nongenomically, but, downstream of initiation sites are similar or shared. Some of these effects end genomically. The actions include hormone-directed angiogenesis, modulation of activities of plasma membrane ion transporters, regulation of the state of the actin cytoskeleton and stimulation of cancer cell proliferation, including breast and, surprisingly, thyroid cancer.
KW - Actin
KW - Angiogenesis
KW - Estradiol
KW - Nuclear receptors
KW - Thyroxine
KW - Triiodothyronine
KW - Tumor cell proliferation
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U2 - 10.2174/187152209789000696
DO - 10.2174/187152209789000696
M3 - Article
AN - SCOPUS:70350028153
VL - 9
SP - 84
EP - 89
JO - Anti-Infective Agents in Medicinal Chemistry
JF - Anti-Infective Agents in Medicinal Chemistry
SN - 2211-3525
IS - 2
ER -