Silica nanohybrids integrated with CuInS2/ZnS quantum dots and magnetite nanocrystals: Multifunctional agents for dual-modality imaging and drug delivery

Jen Chieh Hsu, Chih Ching Huang, Keng Liang Ou, Norman Lu, Fu Der Mai, Jem Kun Chen, Jia Yaw Chang

研究成果: 雜誌貢獻文章

46 引文 (Scopus)

摘要

A strategy is presented for the synthesis of dual-modality and theranostic silica (SiO2) nanohybrids that exert excellent properties for drug delivery vehicles as well as optical and magnetic resonance imaging. SiO 2 nanohybrids are composed of CuInS2/ZnS quantum dots and magnetite nanocrystals, with an outside SiO2 shell grafted with poly(ethyleneglycol) and amine groups to provide better biocompatibility and allow subsequent bioconjugation, respectively. The synthesized nanohybrids are of ultra-small size (diameter <30 nm) and highly monodispersed and stable in aqueous suspension. In vitro results showed that the SiO2 nanohybrids were efficiently taken up by the cells and localized in the intracellular vesicles, emitting strong fluorescence from the cytoplasm and nearby nucleus. It was also demonstrated that SiO2 nanohybrids could be used as a new class of magnetic resonance imaging probes, demonstrating a high spin-spin (T2) relaxivity (r2 = 214 mM-1 s-1). The Pt(iv) anticancer drug, c,c,t-[Pt(NH3) 2Cl2(O2CCH2CH2CO 2H)2], was used as a model drug to attach to the surface of dual-modality SiO2 nanohybrids by using n-ethyl-N′-(3- dimethylaminopropyl)carbodiimide and hydroxysuccinimide as the activating agents. The drug readily formed amide linkages with amines on the surface of the SiO2 nanohybrids, resulting in Pt(iv)-conjugated SiO2 nanohybrids. The results reveal that the Pt(iv)-conjugated SiO2 nanohybrids show higher cytotoxicity than the free Pt(iv) anticancer drug, indicating the potential for using the obtained multifunctional SiO2 nanohybrids simultaneously as highly effective dual-modality imaging probes for cancer diagnosis and chemotherapy.

原文英語
頁(從 - 到)19257-19266
頁數10
期刊Journal of Materials Chemistry
21
發行號48
DOIs
出版狀態已發佈 - 十二月 28 2011

指紋

Ferrosoferric Oxide
Magnetite
Drug delivery
Silicon Dioxide
Nanocrystals
Semiconductor quantum dots
Silica
Magnetic resonance
Imaging techniques
Amines
Pharmaceutical Preparations
Chemotherapy
Cytotoxicity
Biocompatibility
Amides
Carbodiimides
Fluorescence
Suspensions

ASJC Scopus subject areas

  • Materials Chemistry
  • Chemistry(all)

引用此文

Silica nanohybrids integrated with CuInS2/ZnS quantum dots and magnetite nanocrystals : Multifunctional agents for dual-modality imaging and drug delivery. / Hsu, Jen Chieh; Huang, Chih Ching; Ou, Keng Liang; Lu, Norman; Mai, Fu Der; Chen, Jem Kun; Chang, Jia Yaw.

於: Journal of Materials Chemistry, 卷 21, 編號 48, 28.12.2011, p. 19257-19266.

研究成果: 雜誌貢獻文章

Hsu, Jen Chieh ; Huang, Chih Ching ; Ou, Keng Liang ; Lu, Norman ; Mai, Fu Der ; Chen, Jem Kun ; Chang, Jia Yaw. / Silica nanohybrids integrated with CuInS2/ZnS quantum dots and magnetite nanocrystals : Multifunctional agents for dual-modality imaging and drug delivery. 於: Journal of Materials Chemistry. 2011 ; 卷 21, 編號 48. 頁 19257-19266.
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abstract = "A strategy is presented for the synthesis of dual-modality and theranostic silica (SiO2) nanohybrids that exert excellent properties for drug delivery vehicles as well as optical and magnetic resonance imaging. SiO 2 nanohybrids are composed of CuInS2/ZnS quantum dots and magnetite nanocrystals, with an outside SiO2 shell grafted with poly(ethyleneglycol) and amine groups to provide better biocompatibility and allow subsequent bioconjugation, respectively. The synthesized nanohybrids are of ultra-small size (diameter <30 nm) and highly monodispersed and stable in aqueous suspension. In vitro results showed that the SiO2 nanohybrids were efficiently taken up by the cells and localized in the intracellular vesicles, emitting strong fluorescence from the cytoplasm and nearby nucleus. It was also demonstrated that SiO2 nanohybrids could be used as a new class of magnetic resonance imaging probes, demonstrating a high spin-spin (T2) relaxivity (r2 = 214 mM-1 s-1). The Pt(iv) anticancer drug, c,c,t-[Pt(NH3) 2Cl2(O2CCH2CH2CO 2H)2], was used as a model drug to attach to the surface of dual-modality SiO2 nanohybrids by using n-ethyl-N′-(3- dimethylaminopropyl)carbodiimide and hydroxysuccinimide as the activating agents. The drug readily formed amide linkages with amines on the surface of the SiO2 nanohybrids, resulting in Pt(iv)-conjugated SiO2 nanohybrids. The results reveal that the Pt(iv)-conjugated SiO2 nanohybrids show higher cytotoxicity than the free Pt(iv) anticancer drug, indicating the potential for using the obtained multifunctional SiO2 nanohybrids simultaneously as highly effective dual-modality imaging probes for cancer diagnosis and chemotherapy.",
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AU - Hsu, Jen Chieh

AU - Huang, Chih Ching

AU - Ou, Keng Liang

AU - Lu, Norman

AU - Mai, Fu Der

AU - Chen, Jem Kun

AU - Chang, Jia Yaw

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