Silica-modified Fe-doped calcium sulfide nanoparticles for in vitro and in vivo cancer hyperthermia

Steven Yueh Hsiu Wu, Kai Chiang Yang, Ching Li Tseng, Jung Chih Chen, Feng Huei Lin

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

In this study, sulfide-based magnetic Fe-doped CaS nanoparticles modified with a silica layer were investigated for cancer hyperthermia. A polyvinyl pyrrolidone polymer was used as the coupling agent. The developed nanoparticles contained 11.6 wt% iron concentration, and their X-ray diffraction pattern was similar to those of CaS and Fe-CaS nanoparticles. The average particle size was approximately 47.5 nm and homogeneously dispersed in aqueous solutions. The major absorption bands of silica were observed from the FTIR spectrum. The magnetic properties and heating efficiency were also examined. The specific absorption ratio of nanoparticles at a concentration of 10 mg/mL at 37°C in an ethanol carrier fluid was 37.92 W/g, and the nanoparticles would raise the temperature to over 45°C within 15 min. A cytotoxicity analysis revealed that the nanoparticles had good biocompatibility, which indicated that the nanoparticles did not affect cell viability. The therapeutic effects of the nanoparticles were investigated using in vitro and animal studies. Cells seeded with nanoparticles and treated under an AC magnetic field revealed a percentage of cytotoxicity (60%) that was significantly higher from that in other groups. In the animal study, during a hyperthermia period of 15 days, tumor-bearing Balb/c mice that were subcutaneously injected with nanoparticles and exposed to an AC magnetic field manifested a reduction in tumor volume. The newly developed silica-modified Fe-CaS nanoparticles can thus be considered a promising and attractive hyperthermia thermoseed.
原文英語
頁(從 - 到)1139-1149
頁數11
期刊Journal of Nanoparticle Research
13
發行號3
DOIs
出版狀態已發佈 - 三月 2011
對外發佈

ASJC Scopus subject areas

  • 原子與分子物理與光學
  • 凝聚態物理學
  • 建模與模擬
  • 化學 (全部)
  • 材料科學(全部)
  • 生物工程

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