Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

Tsui Chin Huang, Hsin Yi Chang, Cheng Yu Chen, Pei Yi Wu, Hsinyu Lee, Yung Feng Liao, Wen Ming Hsu, Hsuan Cheng Huang, Hsueh Fen Juan

研究成果: 雜誌貢獻文章

52 引文 斯高帕斯(Scopus)

摘要

Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR-124 promotes neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis. Further miR-124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR-124 may suppress the expression of AHR by targeting its 3′-UTR. These results suggest that miR-124 could serve as a potential therapeutic target of neuroblastoma.
原文英語
頁(從 - 到)3582-3586
頁數5
期刊FEBS Letters
585
發行號22
DOIs
出版狀態已發佈 - 十一月 16 2011

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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