Significantly elevated concentration of plasma monocyte chemotactic protein 1 of patients with pelvic inflammatory disease

Pei Ching Hsiao, Po H. Wang, Yi Torng Tee, Shun F. Yang, Pen H. Su, Yi Chen Chen, Long Y. Lin, Hsiu Ting Tsai

研究成果: 雜誌貢獻文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Our goal was to compare the expression of plasma monocyte chemotactic protein 1 (MCP-1) and the gene polymorphism in patients with pelvic inflammatory disease (PID) and healthy controls. The enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were, respectively, used to measure the plasma MCP-1 level and MCP-1 polymorphism in 70 healthy controls and in 64 patients with PID before and after they received routine treatment protocols. We found plasma MCP-1 was significantly elevated in patients with PID compared to that in normal controls and decreased significantly compared to that in patients with PID after they received treatment. The increased expression of plasma MCP-1 was significantly correlated with the cell counts of white blood cells (WBCs) in blood and the level of plasma C-reactive protein (CRP) of patients with PID before they received treatment. There was no association between MCP-1 -2518G/A SNP and its gene expression levels and PID susceptibility. Elevated plasma MCP-1 could be a biological marker for the diagnosis and to be a new strategy for target therapy of pelvic inflammatory disease.

原文英語
頁(從 - 到)549-555
頁數7
期刊Reproductive Sciences
17
發行號6
DOIs
出版狀態已發佈 - 六月 2010
對外發佈Yes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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