Significant synergistic effect of peroxisome proliferator-activated receptor γ C-2821T and diabetes on the risk of ischemic stroke

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

OBJECTIVE - To explore the relationship between the genetic polymorphisms of PPARγ (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARγ would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN AND METHODS - The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARγ were determined by PCR-restriction fragment-length polymorphism. RESULTS - A significant interaction was seen between the -2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the -2821C allele compared with that in those without these two risk factors. CONCLUSIONS - The -2821C allele of PPARγ was a strong predictor of ischemic stroke for diabetic patients.
原文英語
頁(從 - 到)2033-2035
頁數3
期刊Diabetes Care
32
發行號11
DOIs
出版狀態已發佈 - 十一月 2009

Keywords

  • diabetes mellitus
  • cardiovascular risk
  • risk assessment

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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