Significant synergistic effect of peroxisome proliferator-activated receptor γ C-2821T and diabetes on the risk of ischemic stroke

Fang-I Hsieh, Wei Cheng Lo, Huey-Juan Lin, Yi-Chen Hsieh, Li-Ming Lien, Chyi-Huey Bai, Hung Pin Tseng, Hung-Yi Chiou

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

OBJECTIVE - To explore the relationship between the genetic polymorphisms of PPARγ (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARγ would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN AND METHODS - The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARγ were determined by PCR-restriction fragment-length polymorphism. RESULTS - A significant interaction was seen between the -2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the -2821C allele compared with that in those without these two risk factors. CONCLUSIONS - The -2821C allele of PPARγ was a strong predictor of ischemic stroke for diabetic patients.
原文英語
頁(從 - 到)2033-2035
頁數3
期刊Diabetes Care
32
發行號11
DOIs
出版狀態已發佈 - 十一月 2009

指紋

Peroxisome Proliferator-Activated Receptors
Stroke
Genetic Polymorphisms
Alleles
Hypertension
Restriction Fragment Length Polymorphisms
Case-Control Studies
Research Design
Odds Ratio
Polymerase Chain Reaction

Keywords

  • diabetes mellitus
  • cardiovascular risk
  • risk assessment

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

引用此文

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title = "Significant synergistic effect of peroxisome proliferator-activated receptor γ C-2821T and diabetes on the risk of ischemic stroke",
abstract = "OBJECTIVE - To explore the relationship between the genetic polymorphisms of PPARγ (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARγ would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN AND METHODS - The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARγ were determined by PCR-restriction fragment-length polymorphism. RESULTS - A significant interaction was seen between the -2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the -2821C allele compared with that in those without these two risk factors. CONCLUSIONS - The -2821C allele of PPARγ was a strong predictor of ischemic stroke for diabetic patients.",
keywords = "diabetes mellitus, cardiovascular risk, risk assessment, diabetes mellitus, cardiovascular risk, risk assessment",
author = "Fang-I Hsieh and Lo, {Wei Cheng} and Huey-Juan Lin and Yi-Chen Hsieh and Li-Ming Lien and Chyi-Huey Bai and Tseng, {Hung Pin} and Hung-Yi Chiou",
year = "2009",
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T1 - Significant synergistic effect of peroxisome proliferator-activated receptor γ C-2821T and diabetes on the risk of ischemic stroke

AU - Hsieh, Fang-I

AU - Lo, Wei Cheng

AU - Lin, Huey-Juan

AU - Hsieh, Yi-Chen

AU - Lien, Li-Ming

AU - Bai, Chyi-Huey

AU - Tseng, Hung Pin

AU - Chiou, Hung-Yi

PY - 2009/11

Y1 - 2009/11

N2 - OBJECTIVE - To explore the relationship between the genetic polymorphisms of PPARγ (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARγ would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN AND METHODS - The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARγ were determined by PCR-restriction fragment-length polymorphism. RESULTS - A significant interaction was seen between the -2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the -2821C allele compared with that in those without these two risk factors. CONCLUSIONS - The -2821C allele of PPARγ was a strong predictor of ischemic stroke for diabetic patients.

AB - OBJECTIVE - To explore the relationship between the genetic polymorphisms of PPARγ (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARγ would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN AND METHODS - The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARγ were determined by PCR-restriction fragment-length polymorphism. RESULTS - A significant interaction was seen between the -2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the -2821C allele compared with that in those without these two risk factors. CONCLUSIONS - The -2821C allele of PPARγ was a strong predictor of ischemic stroke for diabetic patients.

KW - diabetes mellitus

KW - cardiovascular risk

KW - risk assessment

KW - diabetes mellitus

KW - cardiovascular risk

KW - risk assessment

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