Significant elevation of CLDN16 and HAPLN3 gene expression in human breast cancer

Shou Jen Kuo, Su Yu Chien, Che Lin, Szu Erh Chan, Hsiu Ting Tsai, Dar Ren Chen

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

Cancer development involves the destruction of tight junctions, deprivation of cell polarity, and increased cell mobility. Claudin 16 (CLDN16) is a tight junction protein and plays important roles in the maintenance of cell polarity, cellular arrangement, adhesion, paracellular transport, and ionic permeability of various epithelia. A novel link protein, HAPLN3, functions in hyaluronic acid binding and cell adhesion. Both genes are hypothesized to be related to cancer development and metastasis. The purpose of this study was to estimate the roles of the genes CLDN16 and HAPLN3 in breast cancer. A total of 146 samples were collected from breast cancer tissues and their adjacent normal breast tissues. Reverse transcription and real-time polymerase chain reaction were used to estimate gene expression levels. There were significantly increased gene expression of CLDN16 (p
原文英語
頁(從 - 到)759-766
頁數8
期刊Oncology Reports
24
發行號3
DOIs
出版狀態已發佈 - 九月 2010
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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