Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease

Kuo Shuen Chen, Po Hui Wang, Shun Fa Yang, Ding Bang Lin, Yi Jiun Lin, Dong Yih Kuo, Long Yau Lin, Ming Tsang Wu, Chiao Wen Lin, Sheuan Lee, Ming Chih Chou, Hsiu Ting Tsai, Yih Shou Hsieh

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13 引文 斯高帕斯(Scopus)


Background: We investigated the expressions and ratios of type 1 T helper cell (Th1) cytokines interferon-γ (IFN-γ) and interleukin-2 (IL-2), as well as type 2 T helper cell (Th2) cytokines interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13) and interleukin-10 (IL-10) in pelvic inflammatory disease (PID) patients. Methods: The human cytokine LINCOplex multiplex bead array was used to measure the plasma levels of Th1 and Th2 cytokines in 50 healthy controls, as well as in 41 PID patients before and after routine protocol treatment. Results: Significantly increased expressions of Th1 cytokine IFN-γ (p=0.004), as well as Th2 cytokine IL-5 (p=0.001), and dramatically increased IL-10 (p=0.0001), but significantly decreased expression of Th1 cytokine IL-2 (p=0.029) in PID patients were found after comparison to the control group. The ratio of IFN-γ to IL-13 showed a significant increase, but the ratios of IFN-γ to IL-10 and IL-2 to IL-10 was significantly decreased in PID patients before treatment compared to after treatment and controls. Conclusions: The results indicate that the imbalance and cross-regulation between Th1 and Th2 cytokines pathways is probably contributed to the mechanism of PID.

頁(從 - 到)1609-1616
期刊Clinical Chemistry and Laboratory Medicine
出版狀態已發佈 - 11月 1 2008

ASJC Scopus subject areas

  • 臨床生物化學
  • 生物化學(醫學)


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