Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease

Kuo Shuen Chen, Po Hui Wang, Shun Fa Yang, Ding Bang Lin, Yi Jiun Lin, Dong Yih Kuo, Long Yau Lin, Ming Tsang Wu, Chiao Wen Lin, Sheuan Lee, Ming Chih Chou, Hsiu Ting Tsai, Yih Shou Hsieh

研究成果: 雜誌貢獻文章同行評審

13 引文 斯高帕斯(Scopus)

摘要

Background: We investigated the expressions and ratios of type 1 T helper cell (Th1) cytokines interferon-γ (IFN-γ) and interleukin-2 (IL-2), as well as type 2 T helper cell (Th2) cytokines interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13) and interleukin-10 (IL-10) in pelvic inflammatory disease (PID) patients. Methods: The human cytokine LINCOplex multiplex bead array was used to measure the plasma levels of Th1 and Th2 cytokines in 50 healthy controls, as well as in 41 PID patients before and after routine protocol treatment. Results: Significantly increased expressions of Th1 cytokine IFN-γ (p=0.004), as well as Th2 cytokine IL-5 (p=0.001), and dramatically increased IL-10 (p=0.0001), but significantly decreased expression of Th1 cytokine IL-2 (p=0.029) in PID patients were found after comparison to the control group. The ratio of IFN-γ to IL-13 showed a significant increase, but the ratios of IFN-γ to IL-10 and IL-2 to IL-10 was significantly decreased in PID patients before treatment compared to after treatment and controls. Conclusions: The results indicate that the imbalance and cross-regulation between Th1 and Th2 cytokines pathways is probably contributed to the mechanism of PID.

原文英語
頁(從 - 到)1609-1616
頁數8
期刊Clinical Chemistry and Laboratory Medicine
46
發行號11
DOIs
出版狀態已發佈 - 十一月 1 2008
對外發佈Yes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

指紋 深入研究「Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease」主題。共同形成了獨特的指紋。

引用此