Significance of Nuclear Accumulation of Foxo3a in Esophageal Squamous Cell Carcinoma

Miao Fen Chen, Fu Min Fang, Chang Hsien Lu, Ming Shian Lu, Wen Cheng Chen, Kuan Der Lee, Paul Yang Lin

研究成果: 雜誌貢獻文章

11 引文 (Scopus)

摘要

Purpose: To investigate the value of Foxo3a in predicting the response to neoadjuvant treatment of, and prognosis for, esophageal squamous cell carcinoma. Methods and Materials: Immunohistochemical staining was performed in a retrospective series of 60 biopsied esophageal squamous cell carcinomas, and the correlation between nuclear accumulation of Foxo3a and clinicopathologic features was analyzed, including patient survival. In addition, in vitro biologic changes, radiosensitivity, and in vivo tumorigenicity of esophageal carcinoma cells after experimental manipulation of Foxo3a expression levels were determined. Results: Clinical findings point to a significant correlation between the nuclear accumulation of Foxo3a and the survival rate of esophageal cancer patients. In addition, Foxo3a is a significant predictor for the response to neoadjuvant therapy. In cell culture, irradiation and oxidative stress seemed to result in nuclear accumulation of Foxo3a. Down-regulation of Foxo3a significantly decreased radiosensitivity but had no obvious effect on tumor growth, as measured by a clonogenic assay in vitro and growth delay in vivo. Conclusions: Nuclear accumulation of Foxo3a in tumor cells was correlated with increased radiosensitivity and with improved patient survival. Thus, it is suggested that Foxo3a may be a potential marker for esophageal cancer.
原文英語
頁(從 - 到)1220-1229
頁數10
期刊International Journal of Radiation Oncology Biology Physics
71
發行號4
DOIs
出版狀態已發佈 - 七月 15 2008
對外發佈Yes

指紋

Radiation Tolerance
Neoadjuvant Therapy
cancer
Esophageal Neoplasms
radiation tolerance
Survival
Growth
tumors
Neoplasms
Oxidative Stress
Down-Regulation
Survival Rate
Cell Culture Techniques
prognosis
Staining and Labeling
Carcinoma
staining
markers
manipulators
therapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

引用此文

Significance of Nuclear Accumulation of Foxo3a in Esophageal Squamous Cell Carcinoma. / Chen, Miao Fen; Fang, Fu Min; Lu, Chang Hsien; Lu, Ming Shian; Chen, Wen Cheng; Lee, Kuan Der; Lin, Paul Yang.

於: International Journal of Radiation Oncology Biology Physics, 卷 71, 編號 4, 15.07.2008, p. 1220-1229.

研究成果: 雜誌貢獻文章

Chen, Miao Fen ; Fang, Fu Min ; Lu, Chang Hsien ; Lu, Ming Shian ; Chen, Wen Cheng ; Lee, Kuan Der ; Lin, Paul Yang. / Significance of Nuclear Accumulation of Foxo3a in Esophageal Squamous Cell Carcinoma. 於: International Journal of Radiation Oncology Biology Physics. 2008 ; 卷 71, 編號 4. 頁 1220-1229.
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