Significance and anamnestic response in isolated hepatitis B core antibody-positive individuals 18 years after neonatal hepatitis B virus vaccination in Taiwan

Fu Hsiung Su, Chyi Huey Bai, Fang Yeh Chu, Yu Shiang Lin, Chien Tien Su, Chih Ching Yeh

研究成果: 雜誌貢獻文章

20 引文 (Scopus)

摘要

Aim: To investigate the significance of isolated hepatitis B core antibody (anti-HBc) and to analyze the response to hepatitis B virus (HBV) booster vaccination in young adults with isolated anti-HBc who had been fully vaccinated with HBV vaccine as infants. Materials and methods: We screened 1734 new university entrants who had been fully vaccinated against HBV in infancy for the presence of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and anti-HBc upon university entry. Results positive for isolated anti-HBc were reconfirmed by testing for the presence of HBsAg and anti-HBc once more, and further evaluated for anti-HCV, anti-HIV, and HBV DNA status 6 months later. Students were also offered HBV booster vaccinations at that time. Geometric mean titers (GMT) of anti-HBs after one booster dose of HBV were compared between students with isolated anti-HBc and students with HBV naïve status. Results: The overall prevalence of isolated anti-HBc in our student cohort was 1.2% (21 of 1734). No evidence of occult HBV infection was observed. A " booster" anamnestic response (anti-HBs titer ≥10. mIU/mL) was noted in 95% (20 of 21) of subjects with isolated anti-HBc. After re-measurement of anti-HBc, 13 (62%) of the 21 subjects with isolated anti-HBc were reclassified as having resolved HBV infection with a loss of anti-HBs. In the remaining 8 subjects (38%), isolated anti-HBc was determined to be false positive. The HBV status of these 8 subjects was HBV naïve due to the waning-off effect of anti-HBs of the neonatal HBV vaccination. There was no significant difference in anamnestic response to a single HBV booster dose of vaccine between students with isolated anti-HBc (. n=. 13) and those with HBV naïve (. n=. 323) status (GMT 50.6 vs 47.7. mIU/mL, . P=. 0.90). Conclusion: The presence of isolated anti-HBc 18 years after HBV vaccination can be attributed to post-HBV infection with a loss of anti-HBs and to a decline in anti-HBs elicited by vaccine. A single HBV booster dose of vaccine is recommended for subjects with isolated anti-HBc who were fully vaccinated with HBV vaccine as infants. This finding needs to be replicated in further studies with larger cohorts.

原文英語
頁(從 - 到)4034-4039
頁數6
期刊Vaccine
30
發行號27
DOIs
出版狀態已發佈 - 六月 8 2012

指紋

Hepatitis B Antibodies
Hepatitis B virus
hepatitis B
Taiwan
Vaccination
vaccination
antibodies
students
Students
vaccines
Virus Diseases
Hepatitis B Vaccines
Vaccines
Hepatitis B Surface Antigens
dosage
infection

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

引用此文

@article{dab9d3395ac6414c8b9ee1b6dd115080,
title = "Significance and anamnestic response in isolated hepatitis B core antibody-positive individuals 18 years after neonatal hepatitis B virus vaccination in Taiwan",
abstract = "Aim: To investigate the significance of isolated hepatitis B core antibody (anti-HBc) and to analyze the response to hepatitis B virus (HBV) booster vaccination in young adults with isolated anti-HBc who had been fully vaccinated with HBV vaccine as infants. Materials and methods: We screened 1734 new university entrants who had been fully vaccinated against HBV in infancy for the presence of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and anti-HBc upon university entry. Results positive for isolated anti-HBc were reconfirmed by testing for the presence of HBsAg and anti-HBc once more, and further evaluated for anti-HCV, anti-HIV, and HBV DNA status 6 months later. Students were also offered HBV booster vaccinations at that time. Geometric mean titers (GMT) of anti-HBs after one booster dose of HBV were compared between students with isolated anti-HBc and students with HBV na{\"i}ve status. Results: The overall prevalence of isolated anti-HBc in our student cohort was 1.2{\%} (21 of 1734). No evidence of occult HBV infection was observed. A {"} booster{"} anamnestic response (anti-HBs titer ≥10. mIU/mL) was noted in 95{\%} (20 of 21) of subjects with isolated anti-HBc. After re-measurement of anti-HBc, 13 (62{\%}) of the 21 subjects with isolated anti-HBc were reclassified as having resolved HBV infection with a loss of anti-HBs. In the remaining 8 subjects (38{\%}), isolated anti-HBc was determined to be false positive. The HBV status of these 8 subjects was HBV na{\"i}ve due to the waning-off effect of anti-HBs of the neonatal HBV vaccination. There was no significant difference in anamnestic response to a single HBV booster dose of vaccine between students with isolated anti-HBc (. n=. 13) and those with HBV na{\"i}ve (. n=. 323) status (GMT 50.6 vs 47.7. mIU/mL, . P=. 0.90). Conclusion: The presence of isolated anti-HBc 18 years after HBV vaccination can be attributed to post-HBV infection with a loss of anti-HBs and to a decline in anti-HBs elicited by vaccine. A single HBV booster dose of vaccine is recommended for subjects with isolated anti-HBc who were fully vaccinated with HBV vaccine as infants. This finding needs to be replicated in further studies with larger cohorts.",
keywords = "Booster, HBV, HBV serology, Isolated anti-HBc, Vaccination",
author = "Su, {Fu Hsiung} and Bai, {Chyi Huey} and Chu, {Fang Yeh} and Lin, {Yu Shiang} and Su, {Chien Tien} and Yeh, {Chih Ching}",
year = "2012",
month = "6",
day = "8",
doi = "10.1016/j.vaccine.2012.04.031",
language = "English",
volume = "30",
pages = "4034--4039",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "27",

}

TY - JOUR

T1 - Significance and anamnestic response in isolated hepatitis B core antibody-positive individuals 18 years after neonatal hepatitis B virus vaccination in Taiwan

AU - Su, Fu Hsiung

AU - Bai, Chyi Huey

AU - Chu, Fang Yeh

AU - Lin, Yu Shiang

AU - Su, Chien Tien

AU - Yeh, Chih Ching

PY - 2012/6/8

Y1 - 2012/6/8

N2 - Aim: To investigate the significance of isolated hepatitis B core antibody (anti-HBc) and to analyze the response to hepatitis B virus (HBV) booster vaccination in young adults with isolated anti-HBc who had been fully vaccinated with HBV vaccine as infants. Materials and methods: We screened 1734 new university entrants who had been fully vaccinated against HBV in infancy for the presence of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and anti-HBc upon university entry. Results positive for isolated anti-HBc were reconfirmed by testing for the presence of HBsAg and anti-HBc once more, and further evaluated for anti-HCV, anti-HIV, and HBV DNA status 6 months later. Students were also offered HBV booster vaccinations at that time. Geometric mean titers (GMT) of anti-HBs after one booster dose of HBV were compared between students with isolated anti-HBc and students with HBV naïve status. Results: The overall prevalence of isolated anti-HBc in our student cohort was 1.2% (21 of 1734). No evidence of occult HBV infection was observed. A " booster" anamnestic response (anti-HBs titer ≥10. mIU/mL) was noted in 95% (20 of 21) of subjects with isolated anti-HBc. After re-measurement of anti-HBc, 13 (62%) of the 21 subjects with isolated anti-HBc were reclassified as having resolved HBV infection with a loss of anti-HBs. In the remaining 8 subjects (38%), isolated anti-HBc was determined to be false positive. The HBV status of these 8 subjects was HBV naïve due to the waning-off effect of anti-HBs of the neonatal HBV vaccination. There was no significant difference in anamnestic response to a single HBV booster dose of vaccine between students with isolated anti-HBc (. n=. 13) and those with HBV naïve (. n=. 323) status (GMT 50.6 vs 47.7. mIU/mL, . P=. 0.90). Conclusion: The presence of isolated anti-HBc 18 years after HBV vaccination can be attributed to post-HBV infection with a loss of anti-HBs and to a decline in anti-HBs elicited by vaccine. A single HBV booster dose of vaccine is recommended for subjects with isolated anti-HBc who were fully vaccinated with HBV vaccine as infants. This finding needs to be replicated in further studies with larger cohorts.

AB - Aim: To investigate the significance of isolated hepatitis B core antibody (anti-HBc) and to analyze the response to hepatitis B virus (HBV) booster vaccination in young adults with isolated anti-HBc who had been fully vaccinated with HBV vaccine as infants. Materials and methods: We screened 1734 new university entrants who had been fully vaccinated against HBV in infancy for the presence of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and anti-HBc upon university entry. Results positive for isolated anti-HBc were reconfirmed by testing for the presence of HBsAg and anti-HBc once more, and further evaluated for anti-HCV, anti-HIV, and HBV DNA status 6 months later. Students were also offered HBV booster vaccinations at that time. Geometric mean titers (GMT) of anti-HBs after one booster dose of HBV were compared between students with isolated anti-HBc and students with HBV naïve status. Results: The overall prevalence of isolated anti-HBc in our student cohort was 1.2% (21 of 1734). No evidence of occult HBV infection was observed. A " booster" anamnestic response (anti-HBs titer ≥10. mIU/mL) was noted in 95% (20 of 21) of subjects with isolated anti-HBc. After re-measurement of anti-HBc, 13 (62%) of the 21 subjects with isolated anti-HBc were reclassified as having resolved HBV infection with a loss of anti-HBs. In the remaining 8 subjects (38%), isolated anti-HBc was determined to be false positive. The HBV status of these 8 subjects was HBV naïve due to the waning-off effect of anti-HBs of the neonatal HBV vaccination. There was no significant difference in anamnestic response to a single HBV booster dose of vaccine between students with isolated anti-HBc (. n=. 13) and those with HBV naïve (. n=. 323) status (GMT 50.6 vs 47.7. mIU/mL, . P=. 0.90). Conclusion: The presence of isolated anti-HBc 18 years after HBV vaccination can be attributed to post-HBV infection with a loss of anti-HBs and to a decline in anti-HBs elicited by vaccine. A single HBV booster dose of vaccine is recommended for subjects with isolated anti-HBc who were fully vaccinated with HBV vaccine as infants. This finding needs to be replicated in further studies with larger cohorts.

KW - Booster

KW - HBV

KW - HBV serology

KW - Isolated anti-HBc

KW - Vaccination

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U2 - 10.1016/j.vaccine.2012.04.031

DO - 10.1016/j.vaccine.2012.04.031

M3 - Article

C2 - 22531558

AN - SCOPUS:84861478694

VL - 30

SP - 4034

EP - 4039

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 27

ER -