Signaling pathway and pepsinogen secretion in Helicobacter pylori-infected human gastric adenocarcinoma

Err Cheng Chan, Chien-Tsu Chen, Yuh Ling Lin, Kuei Tian Chen

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Although in vitro studies have suggested that Helicobacter pylori not only attaches to cultured cells but also induces signal transduction events in host cells, the underlying mechanism of H. pylori action has yet to be fully investigated. In the present study, a cytotoxin-positive H. pylori was used to infect and examined for its effect on the stimulation of second messengers in human gastric adenocarcinoma (AGS). Results showed that H. pylori increased cytosolic free calcium concentration [Ca2+]i in host cells in a dose-dependent manner. The increase of [Ca2+]i was due to release from the intracellular Ca2+ store as well as entry to the extracellular Ca2+. H. pylori infection on host cells was also found to induce the generations of inositol phosphates, adenosine 3',5'-cyclic monophosphate, and guanosine 3',5'-cyclic monophosphate, and to stimulate the secretion of pepsinogen.
原文英語
頁(從 - 到)421-425
頁數5
期刊International Journal of Molecular Medicine
3
發行號4
出版狀態已發佈 - 1999

ASJC Scopus subject areas

  • 遺傳學

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