Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation

Kuo Li Pan, Ya Wen Hsiao, Yenn Jiang Lin, Li Wei Lo, Yu Feng Hu, Fa Po Chung, Yung Nan Tsai, Tze Fan Chao, Jo Nan Liao, Chin Yu Lin, Shih Jie Jhuo, Chung-Hsing Lin, Allamsetty Suresh, Rohit Walia, Abigail Louise D. Te, Shinya Yamada, Yao Ting Chang, Shih Lin Chang, Shih Ann Chen

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Background: Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation. Methods and Results: A total of 131 participants (26 healthy individuals and 105 symptomatic PAF patients) were enrolled. PAF patients (54.1±10.8 years) who received catheter ablation therapy were divided into 2 groups: recurrent AF (n=25) and no recurrent AF after catheter ablation (n=80). Peripheral blood mononuclear cells were collected from all subjects to measure LTL. Under 50 years old, LTL in healthy individuals (n=17) was longer than in PAF patients (n=31; 7.34±0.58 kbp vs. 6.44±0.91 kbp, P=0.01). In PAF patients, LTL was positively correlated with left atrial bipolar voltage (R=0.497, P<0.001), and negatively correlated with biatrial scar area (R=−0.570, P<0.001) and left atrial diameter (R=−0.214, P=0.028). LTL was shorter in the patients with recurrent AF than in those without recurrent AF after catheter ablation (5.68±0.82 kbp vs. 6.66±0.71 kbp; P<0.001). On receiver operating characteristic curve analysis, LTL cut-off <6.14 kbp had a specificity of 0.68 and sensitivity of 0.79 to predict recurrent AF after catheter ablation. Conclusions: Young PAF patients (≤50 years) had shorter LTL. Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients.

原文英語
頁(從 - 到)1449-1455
頁數7
期刊Circulation Journal
83
發行號7
DOIs
出版狀態已發佈 - 六月 25 2019

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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