Serum vascular endothelial growth factor-D levels correlate with cervical lymph node metastases in papillary thyroid carcinoma

Chieh Wen Lai, Kuen Yuan Chen, Chin Sheng Hung, Shi Wen Kuo, Yao Jen Chang, Ming Tsan Lin, Kun Che Chang, Ming Hsun Wu

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

The aim of this multicenter study was to evaluate the clinical relevance of serum vascular endothelial growth factor-D (VEGF-D) in papillary thyroid carcinoma (PTC). This prospective study consisted of 74 patients with primary PTC and 15 patients with benign thyroid nodules treated from 2008 to 2009. VEGF-D concentration was compared with patient clinicopathologic features and lymph node metastases. There was no significant difference in mean serum VEGF-D levels between the PTC and benign thyroid nodule groups. Within the PTC group, serum VEGF-D levels were significantly higher in patients with lymph node metastases than in patients without metastases (241.92 vs. 213.89 pg/ml, respectively; P = 0.035). Receiver operating characteristic curve analysis revealed that preoperative serum VEGF-D levels were predictive of lymph node metastases in the patients >45 years. Serum VEGF-D level that was correlated with the presence of cervical lymph node metastases in PTC patients might be a useful prognostic indicator.

原文英語
頁(從 - 到)57-62
頁數6
期刊Growth Factors
29
發行號2-3
DOIs
出版狀態已發佈 - 四月 2011

    指紋

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology
  • Cell Biology

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