Serum Osteopontin Level Correlates with Carotid-Femoral Pulse Wave Velocity in Kidney Transplantation Patients

Ming-Che Lee, Chung-Jen Lee, Bang-Gee Hsu

研究成果: 雜誌貢獻文章同行評審

摘要

BACKGROUND: Osteopontin (OPN) is a potent inhibitor for mineralization and is a potent inducible inhibitor for vascular calcification. This study aimed to investigate the relationships of fasting serum OPN levels and carotid-femoral pulse wave velocity (cfPWV) in kidney transplantation (KT) patients. METHODS: Fasting blood samples were obtained from 50 KT patients. cfPWV were measured by SphygmoCor system. Serum OPN levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA). RESULTS: The univariable linear regression analysis showed that waist circumference ("r": 0.337; "P"=0.017), logarithmically transformed creatinine (log-Creatinine; "r": 0.337; "P"=0.017), pulse pressure ("r": 0.339; "P"=0.016), and the log-OPN concentration ("r": 0.428; "P"=0.002) were positively correlated with cfPWV levels in KT patients. Multivariable forward stepwise linear regression analysis of the significant variables also showed that log-OPN ("β"=0.383, "R" square=0.183, "P"=0.002) was still positively associated with cfPWV levels in KT patients. CONCLUSIONS: These results indicate that serum OPN levels positively associated with cfPWV levels in KT patients.
原文英語
頁(從 - 到)86-93
頁數8
期刊Acta Nephrologica
29
發行號2
DOIs
出版狀態已發佈 - 2015
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