Serum levels of the IgA isotype switch factor TGF-β1 are elevated in patients with COVID-19

Er yi Wang, Hao Chen, Bao qing Sun, Hui Wang, Hui Qi Qu, Yichuan Liu, Xi zhuo Sun, Jingchun Qu, Zhang fu Fang, Lifeng Tian, Yi feng Zeng, Shau Ku Huang, Hakon Hakonarson, Zhi gang Liu

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

We previously observed enhanced immunoglobulin A (IgA) responses in severe COVID-19, which might confer damaging effects. Given the important role of IgA in immune and inflammatory responses, the aim of this study was to investigate the dynamic response of the IgA isotype switch factor TGF-β1 in COVID-19 patients. We observed, in a total of 153 COVID-19 patients, that the serum levels of TGF-β1 were increased significantly at the early and middle stages of COVID-19, and correlated with the levels of SARS-CoV-2-specific IgA, as well as with the APACHE II score in patients with severe disease. In view of the genetic association of the TGF-β1 activator THBS3 with severe COVID-19 identified by the COVID-19 Host Genetics Initiative, this study suggests TGF-β1 may play a key role in COVID-19.

原文英語
頁(從 - 到)1819-1824
頁數6
期刊FEBS Letters
595
發行號13
DOIs
出版狀態已發佈 - 7月 2021
對外發佈

ASJC Scopus subject areas

  • 生物物理學
  • 結構生物學
  • 生物化學
  • 分子生物學
  • 遺傳學
  • 細胞生物學

指紋

深入研究「Serum levels of the IgA isotype switch factor TGF-β1 are elevated in patients with COVID-19」主題。共同形成了獨特的指紋。

引用此