Serum ferritin contributes to racial or geographic disparities in metabolic syndrome in Taiwan

Jung Su Chang, Shiue Ming Lin, Jane C J Chao, Yi Chun Chen, Chi Mei Wang, Ni Hsin Chou, Wen Harn Pan, Chyi Huey Bai

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

Objectives Asians and Pacific Islanders have higher circulating serum ferritin (SF) compared with Caucasians but the clinical significance of this is unclear. There is a higher prevalence of metabolic syndrome (MetS) in Taiwanese Indigenous than Han Chinese. Genetically, Indigenous are related to Austronesians and account for 2 % of Taiwan's population. We tested the hypothesis that accumulation of Fe in the body contributes to the ethnic/racial disparities in MetS in Taiwan. Design A population-based, cross-sectional study. Setting National Nutrition and Health Survey in Taiwan and Penghu Island. Subjects A total of 2638 healthy adults aged ≥19 years. Three ethnic groups were included. Results Han Chinese and Indigenous people had comparable levels of SF. Austronesia origin was independently associated with MetS (OR = 2·61, 95 % CI 2·02, 3·36). After multiple adjustments, the odds for MetS (OR = 2·49, 95 % CI 1·15, 5·28) was significantly higher among Indigenous people in the highest SF tertile compared with those in the lowest tertile. Hakka and Penghu Islanders yielded the lowest risks (OR = 1·08, 95 % CI 0·44, 2·65 and OR = 1·21, 95 % CI 0·52, 2·78, respectively). Indigenous people in the highest SF tertile had increased risk for abnormal levels of fasting glucose (OR = 2·34, 95 % CI 1·27, 4·29), TAG (OR = 1·94, 95 % CI 1·11, 3·39) and HDL-cholesterol (OR = 2·10, 95 % CI 1·18, 3·73) than those in the lowest SF tertile. Conclusions Our results raise the possibility that ethnic/racial differences in body Fe store susceptibility may contribute to racial and geographic disparities in MetS.
原文英語
頁(從 - 到)1498-1506
頁數9
期刊Public Health Nutrition
17
發行號7
DOIs
出版狀態已發佈 - 2014

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health
  • Medicine(all)

指紋 深入研究「Serum ferritin contributes to racial or geographic disparities in metabolic syndrome in Taiwan」主題。共同形成了獨特的指紋。

  • 引用此