Serum brain-derived neurotrophic factor levels were reduced during methamphetamine early withdrawal

Pao Huan Chen, Ming Chi Huang, Ying Ching Lai, Po Yu Chen, Hsing Cheng Liu

研究成果: 雜誌貢獻文章

21 引文 (Scopus)

摘要

Methamphetamine (METH) abuse is an increasing public health problem worldwide. Many of the METH-induced physical and mental problems are associated with the neurotoxic effects of METH. Animal studies have shown that brain-derived neurotrophic factor (BDNF) decreased after repeated amphetamine administration and increased at 30 and 90 days from psychostimulant withdrawal, suggesting that there might be a psychostimulant-induced neuroprotective dysfunction followed by a neuroadaptive process in the brain. However, current research on the role of BDNF in human METH addiction is limited, particularly during early withdrawal. The aim of this study was to assess the serum BDNF levels in METH abusers during the early withdrawal stage. Two groups of subjects were enrolled: (1) 59 DSM-IV METH abusers confirmed by board-certified psychiatrists during the first 3 weeks of withdrawal; (2) 59 age- and sex-matched healthy controls. We found that serum BDNF levels were significantly and constantly lower in the METH abusers during early withdrawal than those of the healthy controls. This indicates that METH abusers might have severe BDNF dysfunction and an impaired neuroprotective function after repetitive METH misuse.

原文英語
頁(從 - 到)482-485
頁數4
期刊Addiction Biology
19
發行號3
DOIs
出版狀態已發佈 - 一月 1 2014

指紋

Methamphetamine
Brain-Derived Neurotrophic Factor
Serum
Amphetamine
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry
Public Health
Brain

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

引用此文

Serum brain-derived neurotrophic factor levels were reduced during methamphetamine early withdrawal. / Chen, Pao Huan; Huang, Ming Chi; Lai, Ying Ching; Chen, Po Yu; Liu, Hsing Cheng.

於: Addiction Biology, 卷 19, 編號 3, 01.01.2014, p. 482-485.

研究成果: 雜誌貢獻文章

Chen, Pao Huan ; Huang, Ming Chi ; Lai, Ying Ching ; Chen, Po Yu ; Liu, Hsing Cheng. / Serum brain-derived neurotrophic factor levels were reduced during methamphetamine early withdrawal. 於: Addiction Biology. 2014 ; 卷 19, 編號 3. 頁 482-485.
@article{59d0fb52133e4acfa220e90d793df3b2,
title = "Serum brain-derived neurotrophic factor levels were reduced during methamphetamine early withdrawal",
abstract = "Methamphetamine (METH) abuse is an increasing public health problem worldwide. Many of the METH-induced physical and mental problems are associated with the neurotoxic effects of METH. Animal studies have shown that brain-derived neurotrophic factor (BDNF) decreased after repeated amphetamine administration and increased at 30 and 90 days from psychostimulant withdrawal, suggesting that there might be a psychostimulant-induced neuroprotective dysfunction followed by a neuroadaptive process in the brain. However, current research on the role of BDNF in human METH addiction is limited, particularly during early withdrawal. The aim of this study was to assess the serum BDNF levels in METH abusers during the early withdrawal stage. Two groups of subjects were enrolled: (1) 59 DSM-IV METH abusers confirmed by board-certified psychiatrists during the first 3 weeks of withdrawal; (2) 59 age- and sex-matched healthy controls. We found that serum BDNF levels were significantly and constantly lower in the METH abusers during early withdrawal than those of the healthy controls. This indicates that METH abusers might have severe BDNF dysfunction and an impaired neuroprotective function after repetitive METH misuse.",
keywords = "Addiction, brain-derived neurotrophic factor, human, methamphetamine, neuroprotection, withdrawal",
author = "Chen, {Pao Huan} and Huang, {Ming Chi} and Lai, {Ying Ching} and Chen, {Po Yu} and Liu, {Hsing Cheng}",
year = "2014",
month = "1",
day = "1",
doi = "10.1111/j.1369-1600.2012.00444.x",
language = "English",
volume = "19",
pages = "482--485",
journal = "Addiction Biology",
issn = "1355-6215",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Serum brain-derived neurotrophic factor levels were reduced during methamphetamine early withdrawal

AU - Chen, Pao Huan

AU - Huang, Ming Chi

AU - Lai, Ying Ching

AU - Chen, Po Yu

AU - Liu, Hsing Cheng

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Methamphetamine (METH) abuse is an increasing public health problem worldwide. Many of the METH-induced physical and mental problems are associated with the neurotoxic effects of METH. Animal studies have shown that brain-derived neurotrophic factor (BDNF) decreased after repeated amphetamine administration and increased at 30 and 90 days from psychostimulant withdrawal, suggesting that there might be a psychostimulant-induced neuroprotective dysfunction followed by a neuroadaptive process in the brain. However, current research on the role of BDNF in human METH addiction is limited, particularly during early withdrawal. The aim of this study was to assess the serum BDNF levels in METH abusers during the early withdrawal stage. Two groups of subjects were enrolled: (1) 59 DSM-IV METH abusers confirmed by board-certified psychiatrists during the first 3 weeks of withdrawal; (2) 59 age- and sex-matched healthy controls. We found that serum BDNF levels were significantly and constantly lower in the METH abusers during early withdrawal than those of the healthy controls. This indicates that METH abusers might have severe BDNF dysfunction and an impaired neuroprotective function after repetitive METH misuse.

AB - Methamphetamine (METH) abuse is an increasing public health problem worldwide. Many of the METH-induced physical and mental problems are associated with the neurotoxic effects of METH. Animal studies have shown that brain-derived neurotrophic factor (BDNF) decreased after repeated amphetamine administration and increased at 30 and 90 days from psychostimulant withdrawal, suggesting that there might be a psychostimulant-induced neuroprotective dysfunction followed by a neuroadaptive process in the brain. However, current research on the role of BDNF in human METH addiction is limited, particularly during early withdrawal. The aim of this study was to assess the serum BDNF levels in METH abusers during the early withdrawal stage. Two groups of subjects were enrolled: (1) 59 DSM-IV METH abusers confirmed by board-certified psychiatrists during the first 3 weeks of withdrawal; (2) 59 age- and sex-matched healthy controls. We found that serum BDNF levels were significantly and constantly lower in the METH abusers during early withdrawal than those of the healthy controls. This indicates that METH abusers might have severe BDNF dysfunction and an impaired neuroprotective function after repetitive METH misuse.

KW - Addiction

KW - brain-derived neurotrophic factor

KW - human

KW - methamphetamine

KW - neuroprotection

KW - withdrawal

UR - http://www.scopus.com/inward/record.url?scp=84899437509&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899437509&partnerID=8YFLogxK

U2 - 10.1111/j.1369-1600.2012.00444.x

DO - 10.1111/j.1369-1600.2012.00444.x

M3 - Article

C2 - 22458544

AN - SCOPUS:84899437509

VL - 19

SP - 482

EP - 485

JO - Addiction Biology

JF - Addiction Biology

SN - 1355-6215

IS - 3

ER -