Serum anti-müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles

Tsung Hsien Lee, Chung Hsien Liu, Chuin Chia Huang, Yi Ling Wu, Yang Tse Shih, Hong Nerng Ho, Yu Shih Yang, Maw Shang Lee

研究成果: 雜誌貢獻文章同行評審

212 引文 斯高帕斯(Scopus)

摘要

BACKGROUND: Anti-Müllerian hormone (AMH) is reported to be a reliable marker of the ovarian response to controlled ovarian stimulation (COS). The objective of this study is to determine whether the serum AMH level can predict ovarian hyperstimulation syndrome (OHSS) prior to selection of COS protocols. METHODS: A cohort of 262 IVF cycles was investigated prospectively, in order to evaluate the predictive value for OHSS by means of certain risk factors, including age, body mass index (BMI), serum estradiol (E2) level, number of retrieved oocytes and basal serum AMH level. RESULTS: The basal serum AMH level predicted OHSS better than age and BMI with a sensitivity of 90.5% and specificity of 81.3%. Both the basal serum AMH level (odds ratio: 1.7856, P = 0.0003) and serum E2 level on the day of HCG administration (odds ratio: 1.0005, P = 0.0455) proved to be significant predictors of OHSS by logistic regression analysis. However, age (odds ratio: 0.9346, P = 0.049) was the only significant factor for prediction of clinical pregnancy. CONCLUSIONS: The basal serum AMH level could be utilized effectively to predict OHSS and thus to direct the selection of mild COS protocols.
原文英語
頁(從 - 到)160-167
頁數8
期刊Human Reproduction
23
發行號1
DOIs
出版狀態已發佈 - 一月 1 2008
對外發佈

ASJC Scopus subject areas

  • 生殖醫學
  • 婦產科

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