Serotype competence and penicillin resistance in Streptococcus pneumoniae

Yu Chia Hsieh, Jin Town Wang, Wen Sen Lee, Po Ren Hsueh, Pei Lan Shao, Luan Yin Chang, Chun Yi Lu, Chin Yun Lee, Fu Yuan Huang, Li Min Huang

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27 引文 斯高帕斯(Scopus)


From 2003 to 2005, we prospectively collected 118 isolates of pneumococci belonging to 7 serotypes to investigate their competence under the influence of the synthetic competence-stimulating peptides. The degree of competence of the various serotypes differed significantly. Serotype 6B had the highest competence, followed by serotypes 14, 19F, 9V, 23F, 3, and 18C. Isolates belonging to serotype 6B had greater genetic diversity than isolates belonging to serotype 3, which has high genetic clustering. Isolates belonging to serotypes 3 and 18C that were 100% sensitive to penicillin were significantly less competent than isolates belonging to serotypes 6B, 14, 19F, 9V, and 23F, which were frequently resistant to penicillin. Under the 7-valent pneumococcal conjugate vaccine program, enhanced molecular surveillance of virulent clones with higher competence to detect serotype switching will become more important.

頁(從 - 到)1709-1714
期刊Emerging Infectious Diseases
出版狀態已發佈 - 十一月 2006

ASJC Scopus subject areas

  • Microbiology (medical)

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