Serotonin transporter mRNA expression is decreased by lamivudine and ribavirin and increased by interferon in immune cells

C. W. Tsao, Y. S. Lin, J. T. Cheng, W. W. Chang, C. L. Chen, S. R. Wu, C. W. Fan, H. Y. Lo

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10 引文 斯高帕斯(Scopus)

摘要

Clinical reports document that depression as a side effect is more prevalent in hepatic patients given interferon (IFN)-α therapy than in those given lamivudine. The mechanisms, however, are poorly understood. Serotonin transporter (5-HTT), via uptake of serotonin (5-HT) into presynaptic serotoninergic neurons, is an initial action site for antidepressants. Real-time polymerase chain reaction (PCR) was used to quantify 5-HTT mRNA expression in immune cells in order to evaluate whether 5-HTT acted as an indicator of depression. Results showed that the 5-HTT mRNA expression was much higher in T-cell and B-cell lines than that in a monocytic cell line. Treatment with either lamivudine or ribavirin reduced the 5-HTT mRNA expression, protein level and 5-HT uptake in T-cell line. Treatment with IFN-α, however, increased those levels in the same group. A similar effect was observed in peripheral blood mononuclear cells (PBMC). Mimicking clinical use by treating PBMC with a combination of IFN-α and ribavirin increased the 5-HTT mRNA expression level. Our study indicates that these therapeutic drugs regulate 5-HTT expression, which implies that 5-HTT might be a trait marker in IFN-α-induced depression after hepatic therapy.
原文英語
頁(從 - 到)106-115
頁數10
期刊Scandinavian Journal of Immunology
63
發行號2
DOIs
出版狀態已發佈 - 2月 1 2006
對外發佈

ASJC Scopus subject areas

  • 免疫學

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