5 引文 (Scopus)

摘要

Background. In this study, the long-term efficacy of hepatitis B virus (HBV) vaccina- tion was assessed using seroprevalence and an age-period-cohort (APC) model of HBV seromarkers among university entrants 30 years after the introduction of the national neonatal HBV vaccination program in Taiwan. Methods. In total, data of 17,611 university entrants who underwent university entrance health examinations between 2005 and 2016 were included. The seroprevalence of the HBV surface antigen (HBsAg) and the levels of the antibody against the HBV surface antigen (anti-HBs) in each year group and sex were calculated. The levels of the antibody against the HBV core antigen were examined only for 2012 and 2016. The APC model was used to analyze the HBV carrier rates. Results. The chronic HBV infection (HBsAg positivity) rate decreased from 9.7% in university students born before June 1974 to < 1.0% in students born after 1992. The prevalence of anti-HBs positivity declined, particularly between the 1984-1988 cohort (78.2%-53.2%) and the 1990-1994 cohort (60.6%-44.4%). Our APC model revealed that the chronic HBV carrier rate among the student population was affected significantly by age, period, and cohort (P < 0:001). Conclusions. HBV vaccination is one of the most effective strategies for preventing HBV infection. However, for complete eradication of HBV infection, the development of strategies that detect vaccination failure more effectively than current strategies do and early implementation of appropriate treatments are both necessary.
原文英語
文章編號e4297
期刊PeerJ
2018
發行號2
DOIs
出版狀態已發佈 - 一月 1 2018

指紋

Hepatitis B virus
Seroepidemiologic Studies
Taiwan
Viruses
seroprevalence
Vaccination
vaccination
Virus Diseases
surface antigens
Surface Antigens
chronic hepatitis B
Chronic Hepatitis B
Hepatitis B Surface Antigens
Students
students
Hepatitis B Core Antigens
infection
Antibodies
antibodies
college students

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

引用此文

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title = "Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program",
abstract = "Background. In this study, the long-term efficacy of hepatitis B virus (HBV) vaccina- tion was assessed using seroprevalence and an age-period-cohort (APC) model of HBV seromarkers among university entrants 30 years after the introduction of the national neonatal HBV vaccination program in Taiwan. Methods. In total, data of 17,611 university entrants who underwent university entrance health examinations between 2005 and 2016 were included. The seroprevalence of the HBV surface antigen (HBsAg) and the levels of the antibody against the HBV surface antigen (anti-HBs) in each year group and sex were calculated. The levels of the antibody against the HBV core antigen were examined only for 2012 and 2016. The APC model was used to analyze the HBV carrier rates. Results. The chronic HBV infection (HBsAg positivity) rate decreased from 9.7{\%} in university students born before June 1974 to < 1.0{\%} in students born after 1992. The prevalence of anti-HBs positivity declined, particularly between the 1984-1988 cohort (78.2{\%}-53.2{\%}) and the 1990-1994 cohort (60.6{\%}-44.4{\%}). Our APC model revealed that the chronic HBV carrier rate among the student population was affected significantly by age, period, and cohort (P < 0:001). Conclusions. HBV vaccination is one of the most effective strategies for preventing HBV infection. However, for complete eradication of HBV infection, the development of strategies that detect vaccination failure more effectively than current strategies do and early implementation of appropriate treatments are both necessary.",
keywords = "Age-period-cohort, Hepatitis B virus, Vaccination",
author = "Hu, {Yang Cheng} and Yeh, {Chih Ching} and Chen, {Ruey Yu} and Su, {Chien Tien} and Wang, {Wen Chang} and Bai, {Chyi Huey} and Chan, {Chi Fei} and Su, {Fu Hsiung}",
year = "2018",
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T1 - Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program

AU - Hu, Yang Cheng

AU - Yeh, Chih Ching

AU - Chen, Ruey Yu

AU - Su, Chien Tien

AU - Wang, Wen Chang

AU - Bai, Chyi Huey

AU - Chan, Chi Fei

AU - Su, Fu Hsiung

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background. In this study, the long-term efficacy of hepatitis B virus (HBV) vaccina- tion was assessed using seroprevalence and an age-period-cohort (APC) model of HBV seromarkers among university entrants 30 years after the introduction of the national neonatal HBV vaccination program in Taiwan. Methods. In total, data of 17,611 university entrants who underwent university entrance health examinations between 2005 and 2016 were included. The seroprevalence of the HBV surface antigen (HBsAg) and the levels of the antibody against the HBV surface antigen (anti-HBs) in each year group and sex were calculated. The levels of the antibody against the HBV core antigen were examined only for 2012 and 2016. The APC model was used to analyze the HBV carrier rates. Results. The chronic HBV infection (HBsAg positivity) rate decreased from 9.7% in university students born before June 1974 to < 1.0% in students born after 1992. The prevalence of anti-HBs positivity declined, particularly between the 1984-1988 cohort (78.2%-53.2%) and the 1990-1994 cohort (60.6%-44.4%). Our APC model revealed that the chronic HBV carrier rate among the student population was affected significantly by age, period, and cohort (P < 0:001). Conclusions. HBV vaccination is one of the most effective strategies for preventing HBV infection. However, for complete eradication of HBV infection, the development of strategies that detect vaccination failure more effectively than current strategies do and early implementation of appropriate treatments are both necessary.

AB - Background. In this study, the long-term efficacy of hepatitis B virus (HBV) vaccina- tion was assessed using seroprevalence and an age-period-cohort (APC) model of HBV seromarkers among university entrants 30 years after the introduction of the national neonatal HBV vaccination program in Taiwan. Methods. In total, data of 17,611 university entrants who underwent university entrance health examinations between 2005 and 2016 were included. The seroprevalence of the HBV surface antigen (HBsAg) and the levels of the antibody against the HBV surface antigen (anti-HBs) in each year group and sex were calculated. The levels of the antibody against the HBV core antigen were examined only for 2012 and 2016. The APC model was used to analyze the HBV carrier rates. Results. The chronic HBV infection (HBsAg positivity) rate decreased from 9.7% in university students born before June 1974 to < 1.0% in students born after 1992. The prevalence of anti-HBs positivity declined, particularly between the 1984-1988 cohort (78.2%-53.2%) and the 1990-1994 cohort (60.6%-44.4%). Our APC model revealed that the chronic HBV carrier rate among the student population was affected significantly by age, period, and cohort (P < 0:001). Conclusions. HBV vaccination is one of the most effective strategies for preventing HBV infection. However, for complete eradication of HBV infection, the development of strategies that detect vaccination failure more effectively than current strategies do and early implementation of appropriate treatments are both necessary.

KW - Age-period-cohort

KW - Hepatitis B virus

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