Serological evidence of subclinical transmission of the 2009 pandemic H1N1 influenza virus outside of Mexico

Day Yu Chao, Kuang Fu Cheng, Tsai Chung Li, Trong Neng Wu, Chiu Ying Chen, Chen An Tsai, Jin Hwa Chen, Hsien Tsai Chiu, Jang Jih Lu, Mei Chi Su, Yu Hsin Liao, Wei Cheng Chan, Ying Hen Hsieh

研究成果: 雜誌貢獻文章

14 引文 (Scopus)

摘要

Background: Relying on surveillance of clinical cases limits the ability to understand the full impact and severity of an epidemic, especially when subclinical cases are more likely to be present in the early stages. Little is known of the infection and transmissibility of the 2009 H1N1 pandemic influenza (pH1N1) virus outside of Mexico prior to clinical cases being reported, and of the knowledge pertaining to immunity and incidence of infection during April-June, which is essential for understanding the nature of viral transmissibility as well as for planning surveillance and intervention of future pandemics. Methodology/Principal Findings: Starting in the fall of 2008, 306 persons from households with schoolchildren in central Taiwan were followed sequentially and serum samples were taken in three sampling periods for haemagglutination inhibition (HI) assay. Age-specific incidence rates were calculated based on seroconversion of antibodies to the pH1N1 virus with an HI titre of 1:40 or more during two periods: April-June and September-October in 2009. The earliest time period with HI titer greater than 40, as well as a four-fold increase of the neutralization titer, was during April 26-May 3. The incidence rates during the pre-epidemic phase (April-June) and the first wave (July-October) of the pandemic were 14.1% and 29.7%, respectively. The transmissibility of the pH1N1 virus during the early phase of the epidemic, as measured by the effective reproductive number R0, was 1.16 (95% confidence interval (CI): 0.98-1.34). Conclusions: Approximately one in every ten persons was infected with the 2009 pH1N1 virus during the pre-epidemic phase in April-June. The lack of age-pattern in seropositivity is unexpected, perhaps highlighting the importance of children as asymptomatic transmitters of influenza in households. Although without virological confirmation, our data raise the question of whether there was substantial pH1N1 transmission in Taiwan before June, when clinical cases were first detected by the surveillance network.

原文英語
文章編號e14555
期刊PLoS One
6
發行號1
DOIs
出版狀態已發佈 - 2011
對外發佈Yes

指紋

H1N1 Subtype Influenza A Virus
Pandemics
pandemic
Orthomyxoviridae
Mexico
Viruses
Hemagglutination
hemagglutination
Taiwan
incidence
viruses
monitoring
households
Incidence
hemagglutination inhibition test
Aptitude
school children
seroconversion
Infection
neutralization

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

引用此文

Chao, D. Y., Cheng, K. F., Li, T. C., Wu, T. N., Chen, C. Y., Tsai, C. A., ... Hsieh, Y. H. (2011). Serological evidence of subclinical transmission of the 2009 pandemic H1N1 influenza virus outside of Mexico. PLoS One, 6(1), [e14555]. https://doi.org/10.1371/journal.pone.0014555

Serological evidence of subclinical transmission of the 2009 pandemic H1N1 influenza virus outside of Mexico. / Chao, Day Yu; Cheng, Kuang Fu; Li, Tsai Chung; Wu, Trong Neng; Chen, Chiu Ying; Tsai, Chen An; Chen, Jin Hwa; Chiu, Hsien Tsai; Lu, Jang Jih; Su, Mei Chi; Liao, Yu Hsin; Chan, Wei Cheng; Hsieh, Ying Hen.

於: PLoS One, 卷 6, 編號 1, e14555, 2011.

研究成果: 雜誌貢獻文章

Chao, DY, Cheng, KF, Li, TC, Wu, TN, Chen, CY, Tsai, CA, Chen, JH, Chiu, HT, Lu, JJ, Su, MC, Liao, YH, Chan, WC & Hsieh, YH 2011, 'Serological evidence of subclinical transmission of the 2009 pandemic H1N1 influenza virus outside of Mexico', PLoS One, 卷 6, 編號 1, e14555. https://doi.org/10.1371/journal.pone.0014555
Chao, Day Yu ; Cheng, Kuang Fu ; Li, Tsai Chung ; Wu, Trong Neng ; Chen, Chiu Ying ; Tsai, Chen An ; Chen, Jin Hwa ; Chiu, Hsien Tsai ; Lu, Jang Jih ; Su, Mei Chi ; Liao, Yu Hsin ; Chan, Wei Cheng ; Hsieh, Ying Hen. / Serological evidence of subclinical transmission of the 2009 pandemic H1N1 influenza virus outside of Mexico. 於: PLoS One. 2011 ; 卷 6, 編號 1.
@article{428b07437205477b8f639ed42ef8c16c,
title = "Serological evidence of subclinical transmission of the 2009 pandemic H1N1 influenza virus outside of Mexico",
abstract = "Background: Relying on surveillance of clinical cases limits the ability to understand the full impact and severity of an epidemic, especially when subclinical cases are more likely to be present in the early stages. Little is known of the infection and transmissibility of the 2009 H1N1 pandemic influenza (pH1N1) virus outside of Mexico prior to clinical cases being reported, and of the knowledge pertaining to immunity and incidence of infection during April-June, which is essential for understanding the nature of viral transmissibility as well as for planning surveillance and intervention of future pandemics. Methodology/Principal Findings: Starting in the fall of 2008, 306 persons from households with schoolchildren in central Taiwan were followed sequentially and serum samples were taken in three sampling periods for haemagglutination inhibition (HI) assay. Age-specific incidence rates were calculated based on seroconversion of antibodies to the pH1N1 virus with an HI titre of 1:40 or more during two periods: April-June and September-October in 2009. The earliest time period with HI titer greater than 40, as well as a four-fold increase of the neutralization titer, was during April 26-May 3. The incidence rates during the pre-epidemic phase (April-June) and the first wave (July-October) of the pandemic were 14.1{\%} and 29.7{\%}, respectively. The transmissibility of the pH1N1 virus during the early phase of the epidemic, as measured by the effective reproductive number R0, was 1.16 (95{\%} confidence interval (CI): 0.98-1.34). Conclusions: Approximately one in every ten persons was infected with the 2009 pH1N1 virus during the pre-epidemic phase in April-June. The lack of age-pattern in seropositivity is unexpected, perhaps highlighting the importance of children as asymptomatic transmitters of influenza in households. Although without virological confirmation, our data raise the question of whether there was substantial pH1N1 transmission in Taiwan before June, when clinical cases were first detected by the surveillance network.",
author = "Chao, {Day Yu} and Cheng, {Kuang Fu} and Li, {Tsai Chung} and Wu, {Trong Neng} and Chen, {Chiu Ying} and Tsai, {Chen An} and Chen, {Jin Hwa} and Chiu, {Hsien Tsai} and Lu, {Jang Jih} and Su, {Mei Chi} and Liao, {Yu Hsin} and Chan, {Wei Cheng} and Hsieh, {Ying Hen}",
year = "2011",
doi = "10.1371/journal.pone.0014555",
language = "English",
volume = "6",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

TY - JOUR

T1 - Serological evidence of subclinical transmission of the 2009 pandemic H1N1 influenza virus outside of Mexico

AU - Chao, Day Yu

AU - Cheng, Kuang Fu

AU - Li, Tsai Chung

AU - Wu, Trong Neng

AU - Chen, Chiu Ying

AU - Tsai, Chen An

AU - Chen, Jin Hwa

AU - Chiu, Hsien Tsai

AU - Lu, Jang Jih

AU - Su, Mei Chi

AU - Liao, Yu Hsin

AU - Chan, Wei Cheng

AU - Hsieh, Ying Hen

PY - 2011

Y1 - 2011

N2 - Background: Relying on surveillance of clinical cases limits the ability to understand the full impact and severity of an epidemic, especially when subclinical cases are more likely to be present in the early stages. Little is known of the infection and transmissibility of the 2009 H1N1 pandemic influenza (pH1N1) virus outside of Mexico prior to clinical cases being reported, and of the knowledge pertaining to immunity and incidence of infection during April-June, which is essential for understanding the nature of viral transmissibility as well as for planning surveillance and intervention of future pandemics. Methodology/Principal Findings: Starting in the fall of 2008, 306 persons from households with schoolchildren in central Taiwan were followed sequentially and serum samples were taken in three sampling periods for haemagglutination inhibition (HI) assay. Age-specific incidence rates were calculated based on seroconversion of antibodies to the pH1N1 virus with an HI titre of 1:40 or more during two periods: April-June and September-October in 2009. The earliest time period with HI titer greater than 40, as well as a four-fold increase of the neutralization titer, was during April 26-May 3. The incidence rates during the pre-epidemic phase (April-June) and the first wave (July-October) of the pandemic were 14.1% and 29.7%, respectively. The transmissibility of the pH1N1 virus during the early phase of the epidemic, as measured by the effective reproductive number R0, was 1.16 (95% confidence interval (CI): 0.98-1.34). Conclusions: Approximately one in every ten persons was infected with the 2009 pH1N1 virus during the pre-epidemic phase in April-June. The lack of age-pattern in seropositivity is unexpected, perhaps highlighting the importance of children as asymptomatic transmitters of influenza in households. Although without virological confirmation, our data raise the question of whether there was substantial pH1N1 transmission in Taiwan before June, when clinical cases were first detected by the surveillance network.

AB - Background: Relying on surveillance of clinical cases limits the ability to understand the full impact and severity of an epidemic, especially when subclinical cases are more likely to be present in the early stages. Little is known of the infection and transmissibility of the 2009 H1N1 pandemic influenza (pH1N1) virus outside of Mexico prior to clinical cases being reported, and of the knowledge pertaining to immunity and incidence of infection during April-June, which is essential for understanding the nature of viral transmissibility as well as for planning surveillance and intervention of future pandemics. Methodology/Principal Findings: Starting in the fall of 2008, 306 persons from households with schoolchildren in central Taiwan were followed sequentially and serum samples were taken in three sampling periods for haemagglutination inhibition (HI) assay. Age-specific incidence rates were calculated based on seroconversion of antibodies to the pH1N1 virus with an HI titre of 1:40 or more during two periods: April-June and September-October in 2009. The earliest time period with HI titer greater than 40, as well as a four-fold increase of the neutralization titer, was during April 26-May 3. The incidence rates during the pre-epidemic phase (April-June) and the first wave (July-October) of the pandemic were 14.1% and 29.7%, respectively. The transmissibility of the pH1N1 virus during the early phase of the epidemic, as measured by the effective reproductive number R0, was 1.16 (95% confidence interval (CI): 0.98-1.34). Conclusions: Approximately one in every ten persons was infected with the 2009 pH1N1 virus during the pre-epidemic phase in April-June. The lack of age-pattern in seropositivity is unexpected, perhaps highlighting the importance of children as asymptomatic transmitters of influenza in households. Although without virological confirmation, our data raise the question of whether there was substantial pH1N1 transmission in Taiwan before June, when clinical cases were first detected by the surveillance network.

UR - http://www.scopus.com/inward/record.url?scp=79251580289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79251580289&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0014555

DO - 10.1371/journal.pone.0014555

M3 - Article

C2 - 21267441

AN - SCOPUS:79251580289

VL - 6

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 1

M1 - e14555

ER -