Sensory and motor recovery after repairing transected cervical roots

Ming Chao Huang, Pei T. Chang, May Jywan Tsai, Huai Sheng Kuo, Wen Chun Kuo, Meng J. Lee, Ming J. Lo, I. H. Lee, Wen Cheng Huang, Liang Ming Lee, Yang Hsin Shih, Liang Shong Lee, Henrich Cheng

研究成果: 雜誌貢獻文章

15 引文 (Scopus)

摘要

Background: Adult mammal sensory axons avulsed through spinal dorsal root traction injuries, especially of the brachial plexus or cauda equina, cannot normally regenerate through axonal outgrowth from the DRG into the spinal cord, thus causing clinical conditions that require neuronal regeneration for sensory recovery and for which no successful treatment has yet been reported. Methods: To evaluate the sensory recovery of the forelimb after transection of their left cervical dorsal and ventral roots (C6-C8) at their spinal cord junctions, 22 SD rats were randomly assigned to 3 groups: transection only (control 1); transection followed by repair using intercostal nerve grafts and fibrin glue (control 2); transection, repair, and application of aFGF and fibrin glue (experimental group). The following tests were reperformed after retransecting the repaired nerve roots to discount collateral innervation from adjacent nerve roots: motor function (grasping power), mechanical sensitivity to pain and touch (foot-withdrawal response to mechanical stimuli), temperature sensitivity (foot-withdrawal response to cold stimulus), and electrophysiologic sensory responses (measurement of cortical SEP). Results: After transection and repair, the experimental group rats showed recovery in both motor (grasping power) and sensory (touch, pain, and temperature sensation) nerve functions. Neuronal regeneration was confirmed by the reappearance of cortical SEP and by its disappearance after retransection of the repaired cervical nerve roots. Conclusion: Using our strategy for repairing transected cervical nerve roots, motor and sensory recovery was achieved in adult rats. The success of our study highlights possible treatment options for humans with avulsion injuries of the dorsal roots from the spinal cord.
原文英語
期刊Surgical Neurology
68
發行號5 SUPPL.
DOIs
出版狀態已發佈 - 十一月 2007

指紋

Spinal Nerve Roots
Spinal Cord
Fibrin Tissue Adhesive
Touch
Foot
Regeneration
Intercostal Nerves
Cauda Equina
Pain
Temperature
Forelimb
Brachial Plexus
Diagnosis-Related Groups
Wounds and Injuries
Traction
Axons
Mammals
Transplants
Therapeutics
Power (Psychology)

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

引用此文

Huang, M. C., Chang, P. T., Tsai, M. J., Kuo, H. S., Kuo, W. C., Lee, M. J., ... Cheng, H. (2007). Sensory and motor recovery after repairing transected cervical roots. Surgical Neurology, 68(5 SUPPL.). https://doi.org/10.1016/j.surneu.2006.09.031

Sensory and motor recovery after repairing transected cervical roots. / Huang, Ming Chao; Chang, Pei T.; Tsai, May Jywan; Kuo, Huai Sheng; Kuo, Wen Chun; Lee, Meng J.; Lo, Ming J.; Lee, I. H.; Huang, Wen Cheng; Lee, Liang Ming; Shih, Yang Hsin; Lee, Liang Shong; Cheng, Henrich.

於: Surgical Neurology, 卷 68, 編號 5 SUPPL., 11.2007.

研究成果: 雜誌貢獻文章

Huang, MC, Chang, PT, Tsai, MJ, Kuo, HS, Kuo, WC, Lee, MJ, Lo, MJ, Lee, IH, Huang, WC, Lee, LM, Shih, YH, Lee, LS & Cheng, H 2007, 'Sensory and motor recovery after repairing transected cervical roots', Surgical Neurology, 卷 68, 編號 5 SUPPL.. https://doi.org/10.1016/j.surneu.2006.09.031
Huang, Ming Chao ; Chang, Pei T. ; Tsai, May Jywan ; Kuo, Huai Sheng ; Kuo, Wen Chun ; Lee, Meng J. ; Lo, Ming J. ; Lee, I. H. ; Huang, Wen Cheng ; Lee, Liang Ming ; Shih, Yang Hsin ; Lee, Liang Shong ; Cheng, Henrich. / Sensory and motor recovery after repairing transected cervical roots. 於: Surgical Neurology. 2007 ; 卷 68, 編號 5 SUPPL.
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title = "Sensory and motor recovery after repairing transected cervical roots",
abstract = "Background: Adult mammal sensory axons avulsed through spinal dorsal root traction injuries, especially of the brachial plexus or cauda equina, cannot normally regenerate through axonal outgrowth from the DRG into the spinal cord, thus causing clinical conditions that require neuronal regeneration for sensory recovery and for which no successful treatment has yet been reported. Methods: To evaluate the sensory recovery of the forelimb after transection of their left cervical dorsal and ventral roots (C6-C8) at their spinal cord junctions, 22 SD rats were randomly assigned to 3 groups: transection only (control 1); transection followed by repair using intercostal nerve grafts and fibrin glue (control 2); transection, repair, and application of aFGF and fibrin glue (experimental group). The following tests were reperformed after retransecting the repaired nerve roots to discount collateral innervation from adjacent nerve roots: motor function (grasping power), mechanical sensitivity to pain and touch (foot-withdrawal response to mechanical stimuli), temperature sensitivity (foot-withdrawal response to cold stimulus), and electrophysiologic sensory responses (measurement of cortical SEP). Results: After transection and repair, the experimental group rats showed recovery in both motor (grasping power) and sensory (touch, pain, and temperature sensation) nerve functions. Neuronal regeneration was confirmed by the reappearance of cortical SEP and by its disappearance after retransection of the repaired cervical nerve roots. Conclusion: Using our strategy for repairing transected cervical nerve roots, motor and sensory recovery was achieved in adult rats. The success of our study highlights possible treatment options for humans with avulsion injuries of the dorsal roots from the spinal cord.",
keywords = "Cervical root, Cholerotoxin B-horseradish peroxidase retrograde axonal labeling, Regeneration, Somatosensory-evoked potential",
author = "Huang, {Ming Chao} and Chang, {Pei T.} and Tsai, {May Jywan} and Kuo, {Huai Sheng} and Kuo, {Wen Chun} and Lee, {Meng J.} and Lo, {Ming J.} and Lee, {I. H.} and Huang, {Wen Cheng} and Lee, {Liang Ming} and Shih, {Yang Hsin} and Lee, {Liang Shong} and Henrich Cheng",
year = "2007",
month = "11",
doi = "10.1016/j.surneu.2006.09.031",
language = "English",
volume = "68",
journal = "World Neurosurgery",
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T1 - Sensory and motor recovery after repairing transected cervical roots

AU - Huang, Ming Chao

AU - Chang, Pei T.

AU - Tsai, May Jywan

AU - Kuo, Huai Sheng

AU - Kuo, Wen Chun

AU - Lee, Meng J.

AU - Lo, Ming J.

AU - Lee, I. H.

AU - Huang, Wen Cheng

AU - Lee, Liang Ming

AU - Shih, Yang Hsin

AU - Lee, Liang Shong

AU - Cheng, Henrich

PY - 2007/11

Y1 - 2007/11

N2 - Background: Adult mammal sensory axons avulsed through spinal dorsal root traction injuries, especially of the brachial plexus or cauda equina, cannot normally regenerate through axonal outgrowth from the DRG into the spinal cord, thus causing clinical conditions that require neuronal regeneration for sensory recovery and for which no successful treatment has yet been reported. Methods: To evaluate the sensory recovery of the forelimb after transection of their left cervical dorsal and ventral roots (C6-C8) at their spinal cord junctions, 22 SD rats were randomly assigned to 3 groups: transection only (control 1); transection followed by repair using intercostal nerve grafts and fibrin glue (control 2); transection, repair, and application of aFGF and fibrin glue (experimental group). The following tests were reperformed after retransecting the repaired nerve roots to discount collateral innervation from adjacent nerve roots: motor function (grasping power), mechanical sensitivity to pain and touch (foot-withdrawal response to mechanical stimuli), temperature sensitivity (foot-withdrawal response to cold stimulus), and electrophysiologic sensory responses (measurement of cortical SEP). Results: After transection and repair, the experimental group rats showed recovery in both motor (grasping power) and sensory (touch, pain, and temperature sensation) nerve functions. Neuronal regeneration was confirmed by the reappearance of cortical SEP and by its disappearance after retransection of the repaired cervical nerve roots. Conclusion: Using our strategy for repairing transected cervical nerve roots, motor and sensory recovery was achieved in adult rats. The success of our study highlights possible treatment options for humans with avulsion injuries of the dorsal roots from the spinal cord.

AB - Background: Adult mammal sensory axons avulsed through spinal dorsal root traction injuries, especially of the brachial plexus or cauda equina, cannot normally regenerate through axonal outgrowth from the DRG into the spinal cord, thus causing clinical conditions that require neuronal regeneration for sensory recovery and for which no successful treatment has yet been reported. Methods: To evaluate the sensory recovery of the forelimb after transection of their left cervical dorsal and ventral roots (C6-C8) at their spinal cord junctions, 22 SD rats were randomly assigned to 3 groups: transection only (control 1); transection followed by repair using intercostal nerve grafts and fibrin glue (control 2); transection, repair, and application of aFGF and fibrin glue (experimental group). The following tests were reperformed after retransecting the repaired nerve roots to discount collateral innervation from adjacent nerve roots: motor function (grasping power), mechanical sensitivity to pain and touch (foot-withdrawal response to mechanical stimuli), temperature sensitivity (foot-withdrawal response to cold stimulus), and electrophysiologic sensory responses (measurement of cortical SEP). Results: After transection and repair, the experimental group rats showed recovery in both motor (grasping power) and sensory (touch, pain, and temperature sensation) nerve functions. Neuronal regeneration was confirmed by the reappearance of cortical SEP and by its disappearance after retransection of the repaired cervical nerve roots. Conclusion: Using our strategy for repairing transected cervical nerve roots, motor and sensory recovery was achieved in adult rats. The success of our study highlights possible treatment options for humans with avulsion injuries of the dorsal roots from the spinal cord.

KW - Cervical root

KW - Cholerotoxin B-horseradish peroxidase retrograde axonal labeling

KW - Regeneration

KW - Somatosensory-evoked potential

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