Self, cortical midline structures and the resting state: Implications for Alzheimer's disease

Marina Weiler, Georg Northoff, Benito Pereira Damasceno, Marcio Luiz Figueredo Balthazar

研究成果: 雜誌貢獻回顧型文獻同行評審

14 引文 斯高帕斯(Scopus)

摘要

Different aspects of the self have been reported to be affected in many neurological or psychiatric diseases such as Alzheimer's disease (AD), including mainly higher-level cognitive self-unawareness. This higher sense of self-awareness is most likely related to and dependent on episodic memory, due to the proper integration of ourselves in time, with a permanent conservation of ourselves (i.e., sense of continuity across time). Reviewing studies in this field, our objective is thus to raise possible explanations, especially with the help of neuroimaging studies, for where such self-awareness deficits originate in AD patients. We describe not only episodic (and autobiographical memory) impairment in patients, but also the important role of cortical midline structures, the Default Mode Network, and the resting state (intrinsic brain activity) for the processing of self-related information.

原文英語
頁(從 - 到)245-255
頁數11
期刊Neuroscience and Biobehavioral Reviews
68
DOIs
出版狀態已發佈 - 九月 1 2016
對外發佈Yes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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