TY - JOUR
T1 - Self, cortical midline structures and the resting state
T2 - Implications for Alzheimer's disease
AU - Weiler, Marina
AU - Northoff, Georg
AU - Damasceno, Benito Pereira
AU - Balthazar, Marcio Luiz Figueredo
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Different aspects of the self have been reported to be affected in many neurological or psychiatric diseases such as Alzheimer's disease (AD), including mainly higher-level cognitive self-unawareness. This higher sense of self-awareness is most likely related to and dependent on episodic memory, due to the proper integration of ourselves in time, with a permanent conservation of ourselves (i.e., sense of continuity across time). Reviewing studies in this field, our objective is thus to raise possible explanations, especially with the help of neuroimaging studies, for where such self-awareness deficits originate in AD patients. We describe not only episodic (and autobiographical memory) impairment in patients, but also the important role of cortical midline structures, the Default Mode Network, and the resting state (intrinsic brain activity) for the processing of self-related information.
AB - Different aspects of the self have been reported to be affected in many neurological or psychiatric diseases such as Alzheimer's disease (AD), including mainly higher-level cognitive self-unawareness. This higher sense of self-awareness is most likely related to and dependent on episodic memory, due to the proper integration of ourselves in time, with a permanent conservation of ourselves (i.e., sense of continuity across time). Reviewing studies in this field, our objective is thus to raise possible explanations, especially with the help of neuroimaging studies, for where such self-awareness deficits originate in AD patients. We describe not only episodic (and autobiographical memory) impairment in patients, but also the important role of cortical midline structures, the Default Mode Network, and the resting state (intrinsic brain activity) for the processing of self-related information.
KW - Alzheimer's disease
KW - Autobiographical memory
KW - Cortical midline structures
KW - Default mode network
KW - Intrinsic activity
KW - Resting state
KW - Self-awareness
KW - Temporal continuity
UR - http://www.scopus.com/inward/record.url?scp=84973128298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973128298&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2016.05.028
DO - 10.1016/j.neubiorev.2016.05.028
M3 - Review article
C2 - 27235083
AN - SCOPUS:84973128298
VL - 68
SP - 245
EP - 255
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
ER -