Self-assembled binary colloidal crystal monolayers as cell culture substrates

Peng Yuan Wang, Hitesh Pingle, Peter Koegler, Helmut Thissen, Peter Kingshott

研究成果: 雜誌貢獻文章

28 引文 斯高帕斯(Scopus)

摘要

This study investigated the formation of self-assembled binary colloidal crystal (BCC) monolayers using evaporation induced confined area assembly (EICAA), and fabricated a family of various BCCs for cell culture. A library of various BCCs with different structures was established and it was demonstrated that after stabilisation the BCCs have potential to be used as substrates with well-ordered surface topographies and chemistries for manipulating cell-surface interactions. Three cell types including MG63 osteoblasts, L929 fibroblasts, and primary human adipose-derived stem cells (hADSCs) show different responses on selected surfaces (either between BCCs or BCCs vs. flat controls). In general, cell spreading was inhibited on BCCs due to surface topography. However, the chemical composition presented on the BCCs can compensate the topographic effect depending on what combination was used. The ordered topographic and heterogeneous chemical patterns provide a complexity of surface properties and have potential to be selectively modified with desired biomolecules for controlling biointerface interactions.
原文英語
頁(從 - 到)2545-2552
頁數8
期刊Journal of Materials Chemistry B
3
發行號12
DOIs
出版狀態已發佈 - 三月 28 2015
對外發佈Yes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine(all)
  • Chemistry(all)
  • Materials Science(all)

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    Wang, P. Y., Pingle, H., Koegler, P., Thissen, H., & Kingshott, P. (2015). Self-assembled binary colloidal crystal monolayers as cell culture substrates. Journal of Materials Chemistry B, 3(12), 2545-2552. https://doi.org/10.1039/c4tb02006e