Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA

Yi Hwa Lin, Show Mei Chuang, Pei Ching Wu, Chun Liang Chen, Sivakamavalli Jeyachandran, Shou Chen Lo, Hsu Shan Huang, Ming Hon Hou

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

The development of a ligand that is capable of distinguishing among the wide variety of G-quadruplex structures and targeting telomeres to treat cancer is particularly challenging. In this study, the ability of two anthraquinone telomerase inhibitors (NSC749235 and NSC764638) to target telomeric G-quadruplex DNA was probed. We found that these ligands specifically target the potassium form of telomeric G-quadruplex DNA over the DNA counterpart. The characteristic interaction with the telomeric G-quadruplex DNA and the anticancer activities of these ligands were also explored. The results of this present work emphasize our understanding of the binding selectivity of anthraquinone derivatives to G-quadruplex DNA and assists in future drug development for G-quadruplex-specific ligands.
原文英語
文章編號31019
期刊Scientific Reports
6
DOIs
出版狀態已發佈 - 八月 11 2016

ASJC Scopus subject areas

  • 多學科

指紋

深入研究「Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA」主題。共同形成了獨特的指紋。

引用此