Selective discrimination of putrescine and cadaverine based on a Fe3+-morpholinoanthracene ensemble in solution and solid state and logic gate aided biological applications in mixed aqueous medium

Anup Pandith, Chakradhar Dasagrandhi, Hak Ryul Kim, Hong Seok Kim

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

A 9,10-bis(morpholinopropylaminomethyl)anthracene (1)-Fe3+chelate was designed, synthesized, and characterized by FT-IR, 1H-1H COSY and 1H-1H ROESY NMR studies. The in situ-generated Fe3+ ensemble selectively detected putrescine (Put) and cadaverine (Cad) through a turn-off response via a decomplexation process in DMSO-H2O (1:1 v/v) at pH 7.3 (HEPES buffer). Furthermore, the in situ-generated ensemble can effectively differentiate biogenic aliphatic di- and triamines from a broad range of aliphatic monoamines (including basic amino acids) and aromatic amines (including polyamines). The lowest limit of detection (LOD) for Put and Cad were 33 ppb and 120 ppb, respectively, in mixed aqueous medium. The decomplexation aided turn-off response by the sequential addition of Put and Cad furnished good association constants [Ksv = 2.30 × 106 M−1, and 9.95 × 105 M−1 in a HEPES-buffered DMSO-H2O (1:1, v/v) medium, respectively]. Furthermore, highly robust vapor phase detections of Put and Cad were also demonstrated using the fluorescent 1·Fe3+ (1:2) ensemble coated on neutral alumina. Cheap ensemble-coated paper strips selectively detected Cad and Put among a variety of biogenic amines. By utilizing complexation/decomplexation processes aided through sequential addition of Fe3+ and Put/Cad an INHIBIT photonic logic gate and its fluorogenic tracking was demonstrated in primitive- eukaryotic cell lines.
原文英語
頁(從 - 到)842-854
頁數13
期刊Sensors and Actuators, B: Chemical
254
DOIs
出版狀態已發佈 - 2018
對外發佈

ASJC Scopus subject areas

  • 電子、光磁材料
  • 儀器
  • 凝聚態物理學
  • 表面、塗料和薄膜
  • 金屬和合金
  • 電氣與電子工程
  • 材料化學

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