Selected nutraceutic screening by therapeutic effects on doxorubicin-induced chronic kidney disease

Chiung Chi Peng, Chiu Lan Hsieh, Yaw Bee Ker, Hsi Yi Wang, Kuan Chou Chen, Robert Y. Peng

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)


Scope: The number of patients with chronic kidney disease (CKD) are increasing. Interventions such as controlling hypertension and specific pharmacologic options are recommended. Some nutraceutics may have benefits in this regard. Methods and results: Naringenin (a flavanon), catechin (a flavanol), and quercetin (a flavonol) and rutin (a flavonol rutinoside) were tried on CKD in a Sprague Dawley rat model. Results indicated quercetin to be the most effective therapeutic candidate with respect to renal edema, hypertension, serum creatinine, hematocrit, cardiopathy, aorta calcification, glomerular amyloidosis, erythrocyte depletion in bone marrow, collagen deposition, expressions of TNF-α, cleaved caspase-3, IκBα, PPARα, and serum insulin. But quercetin was only partially effective in restoring glomerular filtration rate, albuminuria, serum cholesterol, triglyceride, blood urea nitrogen (BUN), uric acid, malondialdehyde, superoxide dismutase; urinary BUN and urinary creatinine. As for signaling, quercetin was completely effective in alleviating the cleaved caspase-3, being only partially effective in suppressing Bax and Bad, restoring Bcl-2, and rescuing DNA damage. Conclusion: The CKD status cannot to be ameliorated by naringenin, rutin, and catechin. Comparatively, quercetin may be a better therapeutic candidate.

頁(從 - 到)1541-1558
期刊Molecular Nutrition and Food Research
出版狀態已發佈 - 10月 2012

ASJC Scopus subject areas

  • 生物技術
  • 食品科學


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