摘要

Objectives: Brain tumors are found in 1–3% of children with newly onset of seizures. Understanding the impact of seizures on pediatric brain tumors and factors between seizures and brain tumors are crucial. This study aimed to evaluate the association of pediatric brain tumors on seizure occurrence and the relationships between seizures and the diagnosis and prognosis of brain tumors. Methods: In a cohort of 184 children with newly diagnosed brain tumors between August 2012 and September 2017, 56 patients with brain tumor-associated seizures were evaluated for their clinical characteristics, electroencephalography (EEG), tumor pathology, response to anti-epileptic drugs (AEDs) and their seizure outcome. Results: The prevalence of seizures in our cohort of children with brain tumors was 30.4% (n = 56/184). Supratentorial tumors were more commonly associated with seizures than were infratentorial tumors (89.3% vs. 10.7%; P < 0.01). Among patients with tumor-associated seizures, the tumors were most commonly located in the temporal lobe (32.1%), followed by the frontal (21.4%) and parietal lobes (16.1%) and other cortices. Thirty-four patients (60.7%) had benign tumor pathology and 22 patients (39.3%) had malignant tumor pathology; low grade astrocytoma (n = 15; 26.8%) was the most common histology type. Seizure onset at initial presentation was more frequently observed in the patients with benign tumors, whereas the patients with malignant tumors tended to have delayed seizure onset (P < 0.01). On EEGs, focal epileptiform discharges were more commonly seen in benign tumors, whereas focal and diffuse slow waves were most commonly associated with malignant tumors. Levetiracetam was the most commonly prescribed AED to treat brain-tumor-associated seizures. Conclusions: In children with brain tumors, higher seizure frequency with normal neurologic examination was more prevalent in benign tumors, whereas less frequent seizures with focal weakness and signs of increased intracranial pressure were more indicative of malignancy. Delayed onset of seizures was more often observed in the children with malignant brain tumors. Seizure characteristics play an important role in relation to tumor biology and epileptogenesis in pediatric brain tumors.

原文英語
頁(從 - 到)15-21
頁數7
期刊Epilepsy Research
147
DOIs
出版狀態已發佈 - 十一月 1 2018

指紋

Brain Neoplasms
Seizures
Pathology
Neoplasms
etiracetam
Pediatrics
Electroencephalography
Post-Traumatic Epilepsy
Supratentorial Neoplasms
Infratentorial Neoplasms
Parietal Lobe
Astrocytoma
Neurologic Examination
Intracranial Pressure
Frontal Lobe
Temporal Lobe
Pharmaceutical Preparations
Histology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

引用此文

@article{36868ff181944b34874b02f2daa25f8d,
title = "Seizure characteristics are related to tumor pathology in children with brain tumors",
abstract = "Objectives: Brain tumors are found in 1–3{\%} of children with newly onset of seizures. Understanding the impact of seizures on pediatric brain tumors and factors between seizures and brain tumors are crucial. This study aimed to evaluate the association of pediatric brain tumors on seizure occurrence and the relationships between seizures and the diagnosis and prognosis of brain tumors. Methods: In a cohort of 184 children with newly diagnosed brain tumors between August 2012 and September 2017, 56 patients with brain tumor-associated seizures were evaluated for their clinical characteristics, electroencephalography (EEG), tumor pathology, response to anti-epileptic drugs (AEDs) and their seizure outcome. Results: The prevalence of seizures in our cohort of children with brain tumors was 30.4{\%} (n = 56/184). Supratentorial tumors were more commonly associated with seizures than were infratentorial tumors (89.3{\%} vs. 10.7{\%}; P < 0.01). Among patients with tumor-associated seizures, the tumors were most commonly located in the temporal lobe (32.1{\%}), followed by the frontal (21.4{\%}) and parietal lobes (16.1{\%}) and other cortices. Thirty-four patients (60.7{\%}) had benign tumor pathology and 22 patients (39.3{\%}) had malignant tumor pathology; low grade astrocytoma (n = 15; 26.8{\%}) was the most common histology type. Seizure onset at initial presentation was more frequently observed in the patients with benign tumors, whereas the patients with malignant tumors tended to have delayed seizure onset (P < 0.01). On EEGs, focal epileptiform discharges were more commonly seen in benign tumors, whereas focal and diffuse slow waves were most commonly associated with malignant tumors. Levetiracetam was the most commonly prescribed AED to treat brain-tumor-associated seizures. Conclusions: In children with brain tumors, higher seizure frequency with normal neurologic examination was more prevalent in benign tumors, whereas less frequent seizures with focal weakness and signs of increased intracranial pressure were more indicative of malignancy. Delayed onset of seizures was more often observed in the children with malignant brain tumors. Seizure characteristics play an important role in relation to tumor biology and epileptogenesis in pediatric brain tumors.",
keywords = "Brain tumor, Child, EEG, Epilepsy, Management, Seizure",
author = "Tsai, {Min Lan} and Chen, {Chi Long} and Hsieh, {Kevin Li Chun} and Miser, {James S.} and Hsi Chang and Liu, {Yen Lin} and Tai-Tong Wong",
note = "Copyright {\circledC} 2018 Elsevier B.V. All rights reserved.",
year = "2018",
month = "11",
day = "1",
doi = "10.1016/j.eplepsyres.2018.08.007",
language = "English",
volume = "147",
pages = "15--21",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",

}

TY - JOUR

T1 - Seizure characteristics are related to tumor pathology in children with brain tumors

AU - Tsai, Min Lan

AU - Chen, Chi Long

AU - Hsieh, Kevin Li Chun

AU - Miser, James S.

AU - Chang, Hsi

AU - Liu, Yen Lin

AU - Wong, Tai-Tong

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Objectives: Brain tumors are found in 1–3% of children with newly onset of seizures. Understanding the impact of seizures on pediatric brain tumors and factors between seizures and brain tumors are crucial. This study aimed to evaluate the association of pediatric brain tumors on seizure occurrence and the relationships between seizures and the diagnosis and prognosis of brain tumors. Methods: In a cohort of 184 children with newly diagnosed brain tumors between August 2012 and September 2017, 56 patients with brain tumor-associated seizures were evaluated for their clinical characteristics, electroencephalography (EEG), tumor pathology, response to anti-epileptic drugs (AEDs) and their seizure outcome. Results: The prevalence of seizures in our cohort of children with brain tumors was 30.4% (n = 56/184). Supratentorial tumors were more commonly associated with seizures than were infratentorial tumors (89.3% vs. 10.7%; P < 0.01). Among patients with tumor-associated seizures, the tumors were most commonly located in the temporal lobe (32.1%), followed by the frontal (21.4%) and parietal lobes (16.1%) and other cortices. Thirty-four patients (60.7%) had benign tumor pathology and 22 patients (39.3%) had malignant tumor pathology; low grade astrocytoma (n = 15; 26.8%) was the most common histology type. Seizure onset at initial presentation was more frequently observed in the patients with benign tumors, whereas the patients with malignant tumors tended to have delayed seizure onset (P < 0.01). On EEGs, focal epileptiform discharges were more commonly seen in benign tumors, whereas focal and diffuse slow waves were most commonly associated with malignant tumors. Levetiracetam was the most commonly prescribed AED to treat brain-tumor-associated seizures. Conclusions: In children with brain tumors, higher seizure frequency with normal neurologic examination was more prevalent in benign tumors, whereas less frequent seizures with focal weakness and signs of increased intracranial pressure were more indicative of malignancy. Delayed onset of seizures was more often observed in the children with malignant brain tumors. Seizure characteristics play an important role in relation to tumor biology and epileptogenesis in pediatric brain tumors.

AB - Objectives: Brain tumors are found in 1–3% of children with newly onset of seizures. Understanding the impact of seizures on pediatric brain tumors and factors between seizures and brain tumors are crucial. This study aimed to evaluate the association of pediatric brain tumors on seizure occurrence and the relationships between seizures and the diagnosis and prognosis of brain tumors. Methods: In a cohort of 184 children with newly diagnosed brain tumors between August 2012 and September 2017, 56 patients with brain tumor-associated seizures were evaluated for their clinical characteristics, electroencephalography (EEG), tumor pathology, response to anti-epileptic drugs (AEDs) and their seizure outcome. Results: The prevalence of seizures in our cohort of children with brain tumors was 30.4% (n = 56/184). Supratentorial tumors were more commonly associated with seizures than were infratentorial tumors (89.3% vs. 10.7%; P < 0.01). Among patients with tumor-associated seizures, the tumors were most commonly located in the temporal lobe (32.1%), followed by the frontal (21.4%) and parietal lobes (16.1%) and other cortices. Thirty-four patients (60.7%) had benign tumor pathology and 22 patients (39.3%) had malignant tumor pathology; low grade astrocytoma (n = 15; 26.8%) was the most common histology type. Seizure onset at initial presentation was more frequently observed in the patients with benign tumors, whereas the patients with malignant tumors tended to have delayed seizure onset (P < 0.01). On EEGs, focal epileptiform discharges were more commonly seen in benign tumors, whereas focal and diffuse slow waves were most commonly associated with malignant tumors. Levetiracetam was the most commonly prescribed AED to treat brain-tumor-associated seizures. Conclusions: In children with brain tumors, higher seizure frequency with normal neurologic examination was more prevalent in benign tumors, whereas less frequent seizures with focal weakness and signs of increased intracranial pressure were more indicative of malignancy. Delayed onset of seizures was more often observed in the children with malignant brain tumors. Seizure characteristics play an important role in relation to tumor biology and epileptogenesis in pediatric brain tumors.

KW - Brain tumor

KW - Child

KW - EEG

KW - Epilepsy

KW - Management

KW - Seizure

UR - http://www.scopus.com/inward/record.url?scp=85052650210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052650210&partnerID=8YFLogxK

U2 - 10.1016/j.eplepsyres.2018.08.007

DO - 10.1016/j.eplepsyres.2018.08.007

M3 - Article

VL - 147

SP - 15

EP - 21

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

ER -