Segregated neural representation of psychological and somatic-vegetative symptoms in severe major depression

Alexander Heinzel, Simone Grimm, Johannes Beck, Daniel Schuepbach, Daniel Hell, Peter Boesiger, Heinz Boeker, Georg Northoff

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

摘要

Objective: The Beck Depression Inventory (BDI) is probably the most widely used depression scale. It has been suggested that it contains a two-factor structure measuring cognitive-affective (i.e. psychological) and somatic-vegetative depressive symptoms. In this study we aim to evaluate these factors by probing for their neural correlates. Methods: Neural responses evoked by emotional perception, relative to an emotional judgment task, were measured using functional magnetic resonance imaging (fMRI) in 20 medication-free patients with severe MDD. Psychological and somatic-vegetative symptoms were evaluated with the BDI. Results: Psychological symptoms correlated with signal changes in the dorsomedial and right ventrolateral prefrontal cortex, while somatic-vegetative symptoms correlated with signal changes in the pre-genual anterior cingulate cortex. Conclusions: These preliminary findings demonstrate segregated neural representation of psychological and somatic-vegetative symptoms of MDD in different cortical regions. Thus, our results indicate that the two-factor structure of the BDI is related to distinct neural correlates.
原文英語
頁(從 - 到)49-53
頁數5
期刊Neuroscience Letters
456
發行號2
DOIs
出版狀態已發佈 - 六月 5 2009

ASJC Scopus subject areas

  • Neuroscience(all)

指紋 深入研究「Segregated neural representation of psychological and somatic-vegetative symptoms in severe major depression」主題。共同形成了獨特的指紋。

  • 引用此