SEEKING and depression in stroke patients: An exploratory study

Marina Farinelli, Jaak Panksepp, Laura Gestieri, Maria Rosaria Leo, Raffaele Agati, Monica Maffei, Marco Leonardi, Georg Northoff

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)


The concept of SEEKING describes a predisposition to search enthusiastically for rewards in the environment. While SEEKING and its underlying functional anatomy have been extensively investigated in animals, such processes in humans, especially brain-damaged individuals, remain understudied. We therefore conducted an exploratory behavioral study in stroke patients to investigate the effects of brain lesions that anatomically could be interpreted to impact the SEEKING system and predicted relationships to depression. Patients with lesions in anterior, medial, and/or subcortical lesions showed significantly lower SEEKING scores and higher depression scores than nonlesioned subjects in the control group. Based on our data and related work on animals, we propose central involvement of the anterior subcortical-cortical midline system as core of the limbic system in SEEKING in humans.
頁(從 - 到)348-358
期刊Journal of Clinical and Experimental Neuropsychology
出版狀態已發佈 - 4月 1 2013

ASJC Scopus subject areas

  • 神經病學(臨床)
  • 神經內科
  • 臨床心理學


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