Secreted phospholipase A2 type IIA (sPLA2-IIA) activates integrins in an allosteric manner

Yoshikazu Takada, Masaaki Fujita

研究成果: 書貢獻/報告類型章節

4 引文 斯高帕斯(Scopus)

摘要

Secreted phospholipase A2 type IIA (sPLA2-IIA) is a well-established pro-inflammatory protein and has been a major target for drug discovery. However, the mechanism of its signaling action has not been fully understood. We previously found that sPLA2-IIA binds to integrins αvβ3 and α4β1 in human and that this interaction plays a role in sPLA2-IIA’s signaling action. Our recent studies found that sPLA2-IIA activates integrins in an allosteric manner through direct binding to a newly identified binding site of integrins (site 2), which is distinct from the classical RGD-binding site (site 1). The sPLA2-IIA-induced integrin activation may be related to the signaling action of sPLA2-IIA. Since sPLA2-IIA is present in normal human tears in addition to rheumatoid synovial fluid at high concentrations the sPLA2-IIA-mediated integrin activation on leukocytes may be involved in immune responses in normal and pathological conditions.

原文英語
主出版物標題Advances in Experimental Medicine and Biology
發行者Springer New York LLC
頁面103-115
頁數13
925
DOIs
出版狀態已發佈 - 2017

出版系列

名字Advances in Experimental Medicine and Biology
925
ISSN(列印)0065-2598
ISSN(電子)2214-8019

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • 引用此

    Takada, Y., & Fujita, M. (2017). Secreted phospholipase A2 type IIA (sPLA2-IIA) activates integrins in an allosteric manner. 於 Advances in Experimental Medicine and Biology (卷 925, 頁 103-115). (Advances in Experimental Medicine and Biology; 卷 925). Springer New York LLC. https://doi.org/10.1007/5584_2016_95