Secondary metabolites from the stems of Engelhardia roxburghiana and their antitubercular activities

Ho Chen Wu, Ming Jen Cheng, Chien Fang Peng, Shyh Chyun Yang, Hsun Shuo Chang, Chu Hung Lin, Chyi Jia Wang, Ih Sheng Chen

研究成果: 雜誌貢獻文章同行評審

38 引文 斯高帕斯(Scopus)

摘要

Bioassay-guided fractionation of stems of Engelhardia roxburghiana led to isolation of: four diarylheptanoids, engelheptanoxides A-D (1-4); two cyclic diarylheptanoids, engelhardiols A (5) and B (6); one naphthoquinone dimer, engelharquinonol (7); and one 1-tetralone, (4S)-4,6-dihydroxy-1-tetralone (8), along with 24 known compounds (9-32). The structures of 1-8 were by spectroscopic analysis. Compounds 5, 6, 13, 22, and 23 showed antitubercular activity against Mycobacterium tuberculosis H37Rv with MIC values of 72.7, 62.1, 9.1, 15.3, and 70.1 μM, respectively.
原文英語
頁(從 - 到)118-127
頁數10
期刊Phytochemistry
82
DOIs
出版狀態已發佈 - 10月 2012
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學
  • 植物科學
  • 園藝科學

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