Secondary metabolites from the fermented rice of the fungus Monascus purpureus and their bioactivities

Ho Cheng Wu, Ming Jen Cheng, Ming Der Wu, Jih Jung Chen, Yen Lin Chen, Hsun Shuo Chang, Kai Ping Chen

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

Phytochemical investigation of the EtOAc-soluble fraction of the ethanolic extract of a yellow mutant of the fungus Monascus purpureus BCRC 38110 (Eurotiaceae) grown on rice resulted in the isolation of one new azaphilone derivative, monapurpureusone (1), one acetophenone metabolite isolated for the first time from natural source, monapurpureusin (2), along with four known compounds, TW94a (3), ergosterol (4), monascin (5), and ankaflavin (6). The structures and relative configurations of these compounds were elucidated by spectroscopic analyses, including 1D- and 2D-NMR spectroscopy and mass spectrometry, and by the comparison of their NMR data with those of related compounds. Some phytochemicals were evaluated for both anti-inflammatory activity through the measurement of nitric oxide (NO) production levels in lipopolysaccharide (LPS)-stimulated murine-derived macrophages RAW264.7 cell lines and antioxidant activities.
原文英語
頁(從 - 到)3541-3550
頁數10
期刊Natural Product Research
33
發行號24
DOIs
出版狀態已發佈 - 12月 17 2019
對外發佈

ASJC Scopus subject areas

  • 分析化學
  • 生物化學
  • 植物科學
  • 有機化學

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