Second transplantation from HLA 2-loci-mismatched mother for graft failure due to hemophagocytic syndrome after cord blood transplantation

Takayuki Tanaka, Hiroshi Matsubara, Souichi Adachi, Hsi Chang, Hisanori Fujino, Yuri Higashi, Takahiro Yasumi, Michihiro Kobayashi, Ken Ichiro Watanabe, Munehisa Takahashi, Yoshiro Kobayashi, Etsuko Maruya, Hiroh Saji, Tatsutoshi Nakahata

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)

摘要

A 7-year-old girl with acute myelogenous leukemia with multilineage dysplasia received unrelated cord blood transplantation but developed hemophagocytic syndrome (HPS) after sepsis with methicillin-resistant coagulase-negative staphylococci before engraftment. Bone marrow aspiration on day 20 revealed a markedly increased number of activated macrophages showing hemophagocytosis. The presence of donor-type chimera in the bone marrow was confirmed at that time. We therefore quickly started immunosuppressive and antibacterial treatment. Although her condition gradually improved, the patient suffered graft failure due to HPS. She received peripheral blood stem cell transplantation from her HLA 2-loci-mismatched mother on day 54 and continued in complete remission 12 months after the second transplantation. The results in this case suggested that because of fetomaternal microchimerism it may be useful to select an HLA-haploidentical mother as a backup donor for stem cell transplantation.

原文英語
頁(從 - 到)467-469
頁數3
期刊International Journal of Hematology
80
發行號5
DOIs
出版狀態已發佈 - 12月 2004
對外發佈

ASJC Scopus subject areas

  • 血液學

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