SECOND MALIGNANCIES COMPLICATING HODGKIN'S DISEASE IN REMISSION

George P. Canellos, James C. Arseneau, Vincent T. Devita, Jacqueline Whang-Peng, Ralph E.C. Johnson

研究成果: 雜誌貢獻文章

204 引文 斯高帕斯(Scopus)

摘要

The incidence of second tumours Summary occurring in the course of Hodgkin's disease has been investigated in a series of 452 patients treated with standard chemotherapy or radiotherapy, combination chemotherapy alone, intensive radiotherapy alone, or both intensive radiotherapy and combination chemotherapy administered in sequence. 16 tumours were noted. When analysed according to mode of treatment, 6 cases occurred in a group of 62 patients who received both modalities. When analysed for age, sex, and man-years of follow-up, this group appears to have 14·5 times the risk of developing a second tumour. However, that subgroup which had a complete remission after intensive radiotherapy followed by a relapse of disease, prior to receiving combination chemotherapy, had the highest risk with 18·5 times greater incidence of second tumour than expected. It is noteworthy that, of the 16 second tumours, 2 were acute myeloid leukæmia; in both cases a similar chromosomal abnormality (45 chromosomes, C-group deletion) was noted. The mechanism of oncogenesis may represent a combination of the immunosuppressive effects and cellular effects of those forms of treatment.

原文英語
頁(從 - 到)947-949
頁數3
期刊The Lancet
305
發行號7913
DOIs
出版狀態已發佈 - 四月 26 1975
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)

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  • 引用此

    Canellos, G. P., Arseneau, J. C., Devita, V. T., Whang-Peng, J., & Johnson, R. E. C. (1975). SECOND MALIGNANCIES COMPLICATING HODGKIN'S DISEASE IN REMISSION. The Lancet, 305(7913), 947-949. https://doi.org/10.1016/S0140-6736(75)92007-3