Second generation drugs-derivatives of natural antitumor anthracycline antibiotics daunorubicin, doxorubicin and carminomycin

Maria N. Preobrazhenskaya, Anna N. Tevyashova, Eugenia N. Olsufyeva, Kuo Feng Huang, Hsu Shan Huang

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

摘要

Anthracycline antibiotics are among the most effective chemotherapy agents currently in use for cancer treatment; however irreversible cardiac damage is a major dose-limiting toxicity, restricting life-time cumulative dose. Besides, the therapeutic activity of many drugs of this class is low if tumor cells express multidrug resistance mediated by a decreased drug accumulation. With the aim of decreasing toxic side effects and also of finding drugs effective in treatment tumors resistant to existing antitumor drugs, investigations are being carried out widely on the synthesis of different analogues of anthracycline antibiotics and the methods of tumor targeted delivery. The design of new generation potential anticancer agents based on known structural principles was found to produce compounds with significantly increased chemotherapeutical indexes.
原文英語
頁(從 - 到)119-128
頁數10
期刊Journal of Medical Sciences (Taiwan)
26
發行號4
出版狀態已發佈 - 八月 2006
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)

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