TY - JOUR
T1 - Scrub typhus-associated hemophagocytic syndrome
AU - Chen, Y. C.
AU - Chao, T. Y.
AU - Lin, J. C.
PY - 2000
Y1 - 2000
N2 - A patient was admitted to our hospital with fever of unknown origin, lymphadenophathy and moderate anemia. The diagnosis of scrub typhus (tsutsugamushi disease) was established on specific serologic demonstration of antibodies to the cross-reacting proteins OX-K antigen and reaffirmed by successful treatment with doxycycline. The diagnosis of hemophagocytic syndrome (HPS) was made on the cytologic findings of many histiocytes containing phagocytosed blood cells in the marrow aspirate. The hemophagocytosis phenomenon disappeared after the scrub typhus was successfully treated, thus suggesting the relationship between scrub typhus and hemophagocytosis. In a patient with rickettsial diseases including scrub typhus, associated with HPS, it is important to understand the relationship between the two disorders since the prognosis for HPS, if untreated, is very poor.
AB - A patient was admitted to our hospital with fever of unknown origin, lymphadenophathy and moderate anemia. The diagnosis of scrub typhus (tsutsugamushi disease) was established on specific serologic demonstration of antibodies to the cross-reacting proteins OX-K antigen and reaffirmed by successful treatment with doxycycline. The diagnosis of hemophagocytic syndrome (HPS) was made on the cytologic findings of many histiocytes containing phagocytosed blood cells in the marrow aspirate. The hemophagocytosis phenomenon disappeared after the scrub typhus was successfully treated, thus suggesting the relationship between scrub typhus and hemophagocytosis. In a patient with rickettsial diseases including scrub typhus, associated with HPS, it is important to understand the relationship between the two disorders since the prognosis for HPS, if untreated, is very poor.
KW - Hemophagocytic syndrome
KW - Scrub typhus
UR - http://www.scopus.com/inward/record.url?scp=0034110578&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034110578&partnerID=8YFLogxK
U2 - 10.1007/s150100050076
DO - 10.1007/s150100050076
M3 - Article
C2 - 10879646
AN - SCOPUS:0034110578
VL - 28
SP - 178
EP - 179
JO - Infection
JF - Infection
SN - 0300-8126
IS - 3
ER -