Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro

Ray Ling Huang, Yu Ling Huang, Jun Chih Ou, Chien Chih Chen, Feng Lin Hsu, Chungming Chang

研究成果: 雜誌貢獻文章同行評審

83 引文 斯高帕斯(Scopus)

摘要

Using an HBV-producing cell line and inhibition of the expression of the HBsAg and HBeAg as antiviral indicators, a study was conducted on 25 compounds isolated from four Phyllanthus (Euphorbiaceae) plants, including P. amarus Schum. & Thonn., P. multiflorus Willd., P. tenellus Roxb. and P. virgatus Forst. f.. It was found that niranthin (1), nirtetralin (3), hinokinin (5) and geraniin (13) at the non-cytotoxic concentration of 50 μM, suppressed effectively both HBsAg and HBeAg expression, with the highest inhibition at 74.3%, 45.3%; 69.6%, 33.9%; 68.1%, 52.3%; 32.1%, 46.6%, respectively. Of these, niranthin (1) showed the best anti-HBsAg activity, while the most potent anti-HBeAg activity was observed with hinokinin (5).
原文英語
頁(從 - 到)449-453
頁數5
期刊Phytotherapy Research
17
發行號5
DOIs
出版狀態已發佈 - 五月 2003

ASJC Scopus subject areas

  • 藥物發現
  • 有機化學
  • 藥理

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