Screening for C9orf72 repeat expansions in parkinsonian syndromes

Tu Hsueh Yeh, Szu Chia Lai, Yi Hsin Weng, Hung Chou Kuo, Yah Huei Wu-Chou, Chia Ling Huang, Rou Shayn Chen, Hsiu Chen Chang, Bryan Traynor, Chin Song Lu

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23 引文 斯高帕斯(Scopus)

摘要

Parkinsonism might precede, coincide, or follow the behavioral or language-predominant cognitive impairments characteristic of frontotemporal dementia (FTD). In this study, we analyze the hexanucleotide repeat expansions within C9orf72 gene in various parkinsonian syndromes because it is a recently identified important genetic cause of FTD. The expanded hexanucleotide repeat is only identified in our familial FTD patients but not in patients with predominant parkinsonism. The lack of association between abnormal C9orf72 repeat expansion and parkinsonian syndromes might imply pathogenic mechanisms other than tau or Lewy body pathology.
原文英語
期刊Neurobiology of Aging
34
發行號4
DOIs
出版狀態已發佈 - 4月 2013
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ASJC Scopus subject areas

  • 神經病學(臨床)
  • 神經科學 (全部)
  • 老化
  • 發展生物學
  • 老年病學和老年學

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