Screening and risk factors for anal cancer precursors in men infected with HIV in Taiwan

Shu Hsing Cheng, Fang Yeh Chu, Chi Chao Wang, Yu-Mei Hsueh

研究成果: 雜誌貢獻文章

12 引文 (Scopus)

摘要

Homosexual men infected with human immunodeficiency virus (HIV) are at a greater risk of developing anal cancer. Men who are infected with HIV and visited the outpatient clinics in Taoyuan General Hospital were enrolled to this study. During March to December 2011, thin preparation anal Pap smear and human papillomavirus (HPV) genotyping were performed in 230 subjects, of which 69 subjects underwent anoscopic biopsy. Their mean age was 32.9±8.1 years, and 181 (78.6%) men were homosexual. The proportion and 95% confidence interval (CI) of subjects with anal dysplasia in cytology was 23.0% (17.56-28.44), including 13.4% (9.26-18.14) with atypical squamous cells of undetermined significance, 7.0% (3.70-10.30) with low-grade squamous intraepithelial lesions, and 2.6% (0.54-4.66) with high-grade squamous intraepithelial lesions. For participants having atypical squamous cells of undetermined significance or higher grades, multivariate logistic regression models yielded adjusted odds ratios (95% CI) of 12.61 (1.63-97.56) for homosexuality, 1.62 (1.31-2.00) for number of oncogenic HPV types, and 1.01 (1.00-1.02) for number of lifetime sexual partners. For detection of histological grade II or III anal intraepithelial neoplasm in anoscopic biopsies, the sensitivity of sequential tests for oncogenic HPV and cytology with atypical squamous cells of undetermined significance or higher grades was 100%. The positive likelihood ratio was 3.09 (P=0.05). It is important to consider anal cancer precursors among homosexual men who are infected with HIV. Anal cytology and oncogenic HPV genotyping testing are effective screening methods.
原文英語
頁(從 - 到)193-201
頁數9
期刊Journal of Medical Virology
86
發行號2
DOIs
出版狀態已發佈 - 二月 2014

指紋

Anus Neoplasms
Taiwan
HIV
Cell Biology
Logistic Models
Confidence Intervals
Biopsy
Papanicolaou Test
Sexual Partners
Homosexuality
Carcinoma in Situ
Ambulatory Care Facilities
General Hospitals
Odds Ratio
Atypical Squamous Cells of the Cervix
Sexual Minorities
Squamous Intraepithelial Lesions of the Cervix

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

引用此文

Screening and risk factors for anal cancer precursors in men infected with HIV in Taiwan. / Cheng, Shu Hsing; Chu, Fang Yeh; Wang, Chi Chao; Hsueh, Yu-Mei.

於: Journal of Medical Virology, 卷 86, 編號 2, 02.2014, p. 193-201.

研究成果: 雜誌貢獻文章

Cheng, Shu Hsing ; Chu, Fang Yeh ; Wang, Chi Chao ; Hsueh, Yu-Mei. / Screening and risk factors for anal cancer precursors in men infected with HIV in Taiwan. 於: Journal of Medical Virology. 2014 ; 卷 86, 編號 2. 頁 193-201.
@article{2cb17c2168294f5a8ecf5d6174c768d3,
title = "Screening and risk factors for anal cancer precursors in men infected with HIV in Taiwan",
abstract = "Homosexual men infected with human immunodeficiency virus (HIV) are at a greater risk of developing anal cancer. Men who are infected with HIV and visited the outpatient clinics in Taoyuan General Hospital were enrolled to this study. During March to December 2011, thin preparation anal Pap smear and human papillomavirus (HPV) genotyping were performed in 230 subjects, of which 69 subjects underwent anoscopic biopsy. Their mean age was 32.9±8.1 years, and 181 (78.6{\%}) men were homosexual. The proportion and 95{\%} confidence interval (CI) of subjects with anal dysplasia in cytology was 23.0{\%} (17.56-28.44), including 13.4{\%} (9.26-18.14) with atypical squamous cells of undetermined significance, 7.0{\%} (3.70-10.30) with low-grade squamous intraepithelial lesions, and 2.6{\%} (0.54-4.66) with high-grade squamous intraepithelial lesions. For participants having atypical squamous cells of undetermined significance or higher grades, multivariate logistic regression models yielded adjusted odds ratios (95{\%} CI) of 12.61 (1.63-97.56) for homosexuality, 1.62 (1.31-2.00) for number of oncogenic HPV types, and 1.01 (1.00-1.02) for number of lifetime sexual partners. For detection of histological grade II or III anal intraepithelial neoplasm in anoscopic biopsies, the sensitivity of sequential tests for oncogenic HPV and cytology with atypical squamous cells of undetermined significance or higher grades was 100{\%}. The positive likelihood ratio was 3.09 (P=0.05). It is important to consider anal cancer precursors among homosexual men who are infected with HIV. Anal cytology and oncogenic HPV genotyping testing are effective screening methods.",
keywords = "Anal intraepithelial neoplasm, Human immunodeficiency virus (HIV), Human papillomavirus (HPV), Men who have sex with men, Squamous intraepithelial lesion",
author = "Cheng, {Shu Hsing} and Chu, {Fang Yeh} and Wang, {Chi Chao} and Yu-Mei Hsueh",
year = "2014",
month = "2",
doi = "10.1002/jmv.23825",
language = "English",
volume = "86",
pages = "193--201",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Screening and risk factors for anal cancer precursors in men infected with HIV in Taiwan

AU - Cheng, Shu Hsing

AU - Chu, Fang Yeh

AU - Wang, Chi Chao

AU - Hsueh, Yu-Mei

PY - 2014/2

Y1 - 2014/2

N2 - Homosexual men infected with human immunodeficiency virus (HIV) are at a greater risk of developing anal cancer. Men who are infected with HIV and visited the outpatient clinics in Taoyuan General Hospital were enrolled to this study. During March to December 2011, thin preparation anal Pap smear and human papillomavirus (HPV) genotyping were performed in 230 subjects, of which 69 subjects underwent anoscopic biopsy. Their mean age was 32.9±8.1 years, and 181 (78.6%) men were homosexual. The proportion and 95% confidence interval (CI) of subjects with anal dysplasia in cytology was 23.0% (17.56-28.44), including 13.4% (9.26-18.14) with atypical squamous cells of undetermined significance, 7.0% (3.70-10.30) with low-grade squamous intraepithelial lesions, and 2.6% (0.54-4.66) with high-grade squamous intraepithelial lesions. For participants having atypical squamous cells of undetermined significance or higher grades, multivariate logistic regression models yielded adjusted odds ratios (95% CI) of 12.61 (1.63-97.56) for homosexuality, 1.62 (1.31-2.00) for number of oncogenic HPV types, and 1.01 (1.00-1.02) for number of lifetime sexual partners. For detection of histological grade II or III anal intraepithelial neoplasm in anoscopic biopsies, the sensitivity of sequential tests for oncogenic HPV and cytology with atypical squamous cells of undetermined significance or higher grades was 100%. The positive likelihood ratio was 3.09 (P=0.05). It is important to consider anal cancer precursors among homosexual men who are infected with HIV. Anal cytology and oncogenic HPV genotyping testing are effective screening methods.

AB - Homosexual men infected with human immunodeficiency virus (HIV) are at a greater risk of developing anal cancer. Men who are infected with HIV and visited the outpatient clinics in Taoyuan General Hospital were enrolled to this study. During March to December 2011, thin preparation anal Pap smear and human papillomavirus (HPV) genotyping were performed in 230 subjects, of which 69 subjects underwent anoscopic biopsy. Their mean age was 32.9±8.1 years, and 181 (78.6%) men were homosexual. The proportion and 95% confidence interval (CI) of subjects with anal dysplasia in cytology was 23.0% (17.56-28.44), including 13.4% (9.26-18.14) with atypical squamous cells of undetermined significance, 7.0% (3.70-10.30) with low-grade squamous intraepithelial lesions, and 2.6% (0.54-4.66) with high-grade squamous intraepithelial lesions. For participants having atypical squamous cells of undetermined significance or higher grades, multivariate logistic regression models yielded adjusted odds ratios (95% CI) of 12.61 (1.63-97.56) for homosexuality, 1.62 (1.31-2.00) for number of oncogenic HPV types, and 1.01 (1.00-1.02) for number of lifetime sexual partners. For detection of histological grade II or III anal intraepithelial neoplasm in anoscopic biopsies, the sensitivity of sequential tests for oncogenic HPV and cytology with atypical squamous cells of undetermined significance or higher grades was 100%. The positive likelihood ratio was 3.09 (P=0.05). It is important to consider anal cancer precursors among homosexual men who are infected with HIV. Anal cytology and oncogenic HPV genotyping testing are effective screening methods.

KW - Anal intraepithelial neoplasm

KW - Human immunodeficiency virus (HIV)

KW - Human papillomavirus (HPV)

KW - Men who have sex with men

KW - Squamous intraepithelial lesion

UR - http://www.scopus.com/inward/record.url?scp=84890172935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890172935&partnerID=8YFLogxK

U2 - 10.1002/jmv.23825

DO - 10.1002/jmv.23825

M3 - Article

C2 - 24166485

AN - SCOPUS:84890172935

VL - 86

SP - 193

EP - 201

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

IS - 2

ER -